Fig. 1
From: Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?
Receptor-ligand: lock-key. Membrane receptor species within lipid rafts may effect transmembrane signaling following ligand binding, via lateral raft-mediated modulation of their membrane environment. Rotation for example, may impact adjacent exoplasmic domains to provide a code for transmembrane domain interactions and subsequent cytosolic signal propagation