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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn

Fig. 6

Schematic of the mechanism by which excess Fasn promotes LD accumulation in Wdr45 deficient cells. In normal cells, CMA degrades Fasn and LDs, thus suppressing LD accumulation, which is toxic to mouse dopaminergic neurons SN471. However, deletion of Wdr45 impaired CMA. Neither Fasn nor LDs can be degraded; thus, excess Fasn promotes LD formation. Increased LD formation and impaired LD breakdown inhibit cell proliferation which may contribute to the progression of BPAN

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Lipids in Health and Disease

ISSN: 1476-511X