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Table 3 Associations between LDLR polymorphisms and the percentage changes in serum lipid levels after atorvastatin therapy

From: Impact of LDLR polymorphisms on lipid levels and atorvastatin’s efficacy in a northern Chinese adult Han cohort with dyslipidemia

rsID

gDNA_coordinate

wild/mutant

(patients)

P

Δ%TG (wild greater)

Δ%TG (mutant greater)

Δ%TC (wild greater)

Δ%TC (mutant greater)

Δ%LDL-C (wild greater)

Δ%LDL-C (mutant greater)

Δ%HDL-C (wild greater)

Δ%HDL-C (mutant greater)

rs1433099

chr19:g.11242658T > C

21/234

0.461

0.539

0.571

0.429

0.514

0.486

0.02

0.98

rs14158

chr19:g.11242044G > A

94/161

0.707

0.293

0.876

0.124

0.851

0.149

0.639

0.361

rs2738466

chr19:g.11,242,765 A > G

94/161

0.707

0.293

0.876

0.124

0.851

0.149

0.639

0.361

rs5742911

chr19:g.11,243,445 A > G

94/161

0.707

0.293

0.876

0.124

0.851

0.149

0.639

0.361

rs17249057

chr19:g.11243502T > C

94/161

0.707

0.293

0.876

0.124

0.851

0.149

0.639

0.361

rs2738467

chr19:g.11,243,735 C > T

182/73

0.309

0.691

0.024

0.976

0.035

0.965

0.002

0.998

rs55971831

chr19:g.11,243,411 C > A

188/67

0.176

0.824

0.712

0.288

0.862

0.138

0.496

0.504

rs751672818

chr19:g.11243411delC

246/9

0.645

0.355

0.676

0.324

0.337

0.663

0.984

0.016

rs7254521

chr19:g.11,243,422 C > T

253/2

0.5

0.5

0.818

0.182

0.969

0.031

0.682

0.318

rs566918949

chr19:g.11243467G > A

253/2

0.286

0.714

0.238

0.762

0.261

0.739

0.122

0.878

rs568219285

chr19:g.11242719G > A

254/1

0.05

0.95

0.157

0.843

0.876

0.124

0.942

0.058

  1. Note The relative changes in serum lipid levels after atorvastatin therapy were compared by the Wilcoxon rank sum test. Values in bold are statistically significant (P < 0.05). The P values listed in the table represent the null hypothesis, while the remarks in parentheses are indicative of the alternative hypothesis. Δ%TG = 100*(TGpostintervention-TGenrollment)/TGenrollment; Δ%TC = 100*(TCpostintervention-TCenrollment/TCenrollment; Δ%LDL-C = 100*(LDL-Cpostintervention-LDL-Cenrollment/LDL-Cenrollment; Δ%HDL-C = 100*(HDL-Cpostintervention-HDL-Cenrollment/HDL-Cenrollment.
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Lipids in Health and Disease

ISSN: 1476-511X