Fig. 4

Schematic representation illustrating part of the pathogenesis of MASLD. Excessive dietary fat intake triggers multiple hepatic mechanisms, including mitochondrial dysfunction, which induces hepatic lipid accumulation, leading to MASLD. on the other hand, gut microbial dysbiosis is an essential component in the study of MASLD development, and the “liver-gut axis” has been proposed as a new target to drive the complex progression of MASLD.