Fig. 3

LASSO regression analysis of the 19 covariates associated with CVD mortality and Dose–response relationship between PHR and CVD mortality among stroke survivals. Legend: A The screening path corresponds to 19 covariates that contribute to CVD mortality among stroke survivors. B The association between the log-transformed λ and Partial Likelihood Deviance for CVD mortality among stroke survivors. The red dashed line and its error bars represent the average Partial Likelihood Deviance value and the corresponding 95% CI. The left black dashed line represents the optimal λ value obtained when calculating the minimum Partial Likelihood Deviance, while the right black dashed line represents the λ value of the simplest model obtained at one standard error from the minimum Partial Likelihood Deviance. C Dose–response relationship between PHR and CVD mortality among stroke survivals. D Dose–response relationship between HDL-C and CVD mortality among stroke survivals. Three knots (10th, 50th, 90th percentiles) were selected for fitting the restricted cubic spline model, and the median value of PHR (181.91) and HDL-C (1.27 mmol/L) served as the reference point, and models were adjusted for age, sex, marital status, smoking, drinking, thyroid problems, cancer, CHD and CKD. Abbreviation: HDL-C, high-density lipoprotein cholesterol; PHR, platelet-to-high-density lipoprotein cholesterol ratio; CVD, cardiovascular disease; CHD, coronary heart disease; CKD, chronic kidney disease; LASSO, least absolute shrinkage, and selection operator; HR, hazard ratio; CI, confidence interval