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Non-statin lipid-lowering therapy in coronary atherosclerosis regression

Our authors aim to define if a dual lipid-lowering therapy (statin + non-statin drugs) is associated with coronary atherosclerosis regression, estimated by intravascular ultrasound (IVUS), and, to assess the association between dual lipid-lowering-induced changes in low density lipoprotein cholesterol (LDL-C) and non-high-density-lipoprotein cholesterol (non-HDL-C) levels and atherosclerosis regression.

Metabolic effects of PCSK9 inhibition with Evolocumab in subjects with elevated Lp(a)

Nuclear magnetic resonance (NMR) metabolomics is performed on plasma samples derived from 30 individuals with elevated Lp(a) (> 150 mg/dL). Inhibition of PCSK9 with evolocumab markedly reduces VLDL particle concentrations in addition to lowering LDL-C. The extent of reduction in VLDL particles depends on the baseline level of Lp(a). Our authors’ findings suggest a marked effect of evolocumab on VLDL metabolism in subjects with elevated Lp(a).

Fatty acid profile & estimated desaturase activities in whole blood

Our authors investigate if fatty acid profile and estimated desaturase activities (stearoyl CoA-desaturase, delta-5-desaturase and delta-6-desaturase) differ between individuals with metabolically healthy (MH) and unhealthy (MU) phenotypes. They also explored these associations according to BMI categories. This study supports estimated desaturase activities as possible novel biomarkers of metabolic health irrespectively of BMI.

Lipid profile and left ventricular geometry pattern in obese children

Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. Our authors seek to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children.

Call for papers: Lipids as signalling molecules

While once viewed as a passive mode of energy storage, lipids are now well-understood to serve as integral components of biological membranes and to function as key intracellular and extracellular messengers. This collection of papers will address the role of lipids as key signalling molecules in health and disease. We would particularly welcome manuscripts that try to bridge the gap between molecular and biochemical aspects of various lipids and their potential clinical applications/implications.

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Looking for Associate Editor (Biostatistics/ Bioinformatics)

Lipids in Health and Disease is currently looking for a candidate with a strong background in biostatistics and bioinformatics, to join our Editorial Board. The individual would help handle manuscripts in these areas (providing initial assessment of the manuscript’s quality, inviting reviewers, and suggesting revision and final decisions), provide peer review for appropriate manuscripts (when requested), and would be encouraged to submit a review article on an area of expertise to the journal at least once a year (or whenever available after checking with Editor-in-Chief and the publisher). Looking for outstanding researchers with meta-analytic abilities, familiarity with editorial processes, and an h-index of at least 30. Please send queries of interest/ CV's to info@biomedcentral.com, with “Lipids in Health and Disease- Biostatistics and Bioinformatics” in the subject line.

Articles

Editor-in-Chief

A. M. Abd El-Aty, Cairo University, Egypt

Aims and scope

Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.

Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.

Reviewers of the quarter

Lipids in Health and Disease is pleased to implement a new platform of recognition every quarter, for the peer reviewers who provided the best performance along the parameters of acceptance rate, scrutiny of the reviews, completion, accepted-completion %, On time delivery-Completion %, and our Editor-in-Chief's evaluation rate. Please click here, to learn about our Reviewers of the Quarter.

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