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  1. Research

    The Arg282Ser missense mutation in APOA5 gene determines a reduction of triglyceride and LDL-cholesterol in children, together with low serum levels of apolipoprotein A-V

    Apolipoprotein A-V (ApoA-V) is a recognized regulator of plasma triglycerides (TGs), and previous studies have shown associations between variants in APOA5 (apolipoprotein-A5) gene and high TG levels. Recently, a...

    Laura Bertoccini, Federica Sentinelli, Michela Incani, Diego Bailetti, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Efisio Cossu, Andrea Lenzi, Sandro Loche and Marco Giorgio Baroni

    Lipids in Health and Disease 2017 16:179

    Published on: 19 September 2017

  2. Research

    Plasma trans-fatty acids levels and mortality: a cohort study based on 1999–2000 National Health and Nutrition Examination Survey (NHANES)

    Trans-fatty acids (TFAs) occur in small amounts in nature but became widely produced by the food industry. The hazardous effects of different TFA subtypes to human health are controversial. We aimed to evaluat...

    Haibo Li, Qian Zhang, Jiangen Song, Anshi Wang, Yunfei Zou, Lei Ding and Yufeng Wen

    Lipids in Health and Disease 2017 16:176

    Published on: 16 September 2017

  3. Research

    Protective effects of grape seed and skin extract against high-fat-diet-induced lipotoxicity in rat lung

    Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive ...

    Mohamed El Ayed, Safwen Kadri, Selima Smine, Salem Elkahoui, Ferid Limam and Ezzedine Aouani

    Lipids in Health and Disease 2017 16:174

    Published on: 13 September 2017

  4. Research

    The purification of reduced β2-glycoprotein I showed its native activity in vitro

    New evidence has shown that reduced β2-glycoprotein I (β2GPI) has anti-oxidative stress and anti-inflammatory activity. However, the details are still poorly understood. This study aims to prepare stable reduc...

    Saijun Zhou, Ming Lu, Jiantong Zhao, Shuaihui Liu, Xin Li, Rui Zhang, Hongyan Liu and Pei Yu

    Lipids in Health and Disease 2017 16:173

    Published on: 13 September 2017

  5. Research

    The mixed benefit of low lipoprotein(a) in type 2 diabetes

    Lipoprotein(a) (Lp(a)), a variant low-density lipoprotein (LDL), is a major genetic risk factor for cardiovascular disease. It is unknown whether an inverse relationship exists between Lp(a) and β-cell function (...

    Michel P. Hermans, Sylvie A. Ahn and Michel F. Rousseau

    Lipids in Health and Disease 2017 16:171

    Published on: 12 September 2017

  6. Research

    Coronary artery calcium score plays an important role for cardiovascular risk stratification in the statin benefit groups of asymptomatic individuals

    The purpose of this study was to describe and analyze the relationship between statin benefit groups based on statin-intensity class of drugs and coronary artery calcium score (CACS) using multidetector comput...

    Dong-Hyeon Lee, Ho-Joong Youn, Hae-Ok Jung, Kiyuk Chang, Yun-Seok Choi and Jung Im Jung

    Lipids in Health and Disease 2017 16:172

    Published on: 12 September 2017

  7. Research

    Role of Rab5 in the formation of macrophage-derived foam cell

    Foam cells play a key role in the occurrence and pathogenesis of atherosclerosis. Its formation starts with the ingestion of oxidized low-density lipoprotein (oxLDL). The process is associated with Ras related...

    Lokwern Chan, Jin Hong, Junjie Pan, Jian Li, Zhichao Wen, Haiming Shi, Jianping Ding and Xinping Luo

    Lipids in Health and Disease 2017 16:170

    Published on: 12 September 2017

  8. Research

    Associations of the APOB rs693 and rs17240441 polymorphisms with plasma APOB and lipid levels: a meta-analysis

    The associations of the apolipoprotein B gene (APOB) rs693 and rs17240441 polymorphisms with plasma levels of APOB and lipids have been widely explored, but the results were inconclusive. This meta-analysis aimed...

    Caiqin Niu, Zhi Luo, Liuqin Yu, Yang Yang, Yun Chen, Xin Luo, Feiya Lai and Yongyan Song

    Lipids in Health and Disease 2017 16:166

    Published on: 6 September 2017

  9. Research

    Characteristics of lipid metabolism including serum apolipoprotein M levels in patients with primary nephrotic syndrome

    Apolipoprotein M (apoM) is a 26-kD apolipoprotein that is mainly expressed in specific cell types, such as human liver parenchymal cells and kidney proximal renal tubular epithelial cells. ApoM can regulate th...

    Lagu He, Pengfei Wu, Li Tan, Bai Le, Wenhan Du, Ting Shen, Jiali Wu, Zheyi Xiang and Min Hu

    Lipids in Health and Disease 2017 16:167

    Published on: 6 September 2017

  10. Research

    Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case – control study

    Non-alcoholic fatty liver disease (NAFLD) given its association with obesity and diabetes may perhaps exert distinct free fatty acids (FFA) pattern, but the understanding of this phenomenon is limited. To this...

    Rennan Feng, Chao Luo, Chunlong Li, Shanshan Du, Akinkunmi Paul Okekunle, Yanchuan Li, Yang Chen, Tianqi Zi and Yucun Niu

    Lipids in Health and Disease 2017 16:165

    Published on: 4 September 2017

  11. Research

    Effect of oregano essential oil and benzoic acid supplementation to a low-protein diet on meat quality, fatty acid composition, and lipid stability of longissimus thoracis muscle in pigs

    Consumers are becoming increasingly interested in food containing appropriately high concentration of intramuscular fat (IMF) and polyunsaturated fatty acids (PUFA). The supplementation of feed with antioxidan...

    Chuanshang Cheng, Xiaming Zhang, Mao Xia, Zuhong Liu, Hongkui Wei, Zhao Deng, Chao Wang, Siwen Jiang and Jian Peng

    Lipids in Health and Disease 2017 16:164

    Published on: 31 August 2017

  12. Research

    Antioxidant capacity and fatty acids characterization of heat treated cow and buffalo milk

    Antioxidant capacity of milk is largely due to vitamins A, E, carotenoids, zinc, selenium, superoxide dismutase, catalase, glutathione peroxidase and enzyme systems. Cow milk has antioxidant capacity while the...

    Imran Taj Khan, Muhammad Nadeem, Muhammad Imran, Muhammad Ayaz, Muhammad Ajmal, Muhammad Yaqoob Ellahi and Anjum Khalique

    Lipids in Health and Disease 2017 16:163

    Published on: 24 August 2017

  13. Research

    Fractional esterification rate of cholesterol in high-density lipoprotein associates with risk of coronary heart disease

    Fractional esterification rate of cholesterol in high-density lipoprotein (FERHDL) has been found to be closely correlated with atherosclerotic dyslipidemia, especially lipoprotein distributions, and is a potenti...

    Junmeng Liu, Ruiyue Yang, Min Zhou, Wen Mao, Hongxia Li, Haijian Zhao, Shu Wang, Wenxiang Chen, Jun Dong and Qing He

    Lipids in Health and Disease 2017 16:162

    Published on: 24 August 2017

  14. Research

    Prevalence of dyslipidaemia and risk factors in Chinese coal miners: a cross-sectional survey study

    Although coal miners are susceptible to dyslipidaemia owing to their highly risky and stressful working environment as well as unhealthy lifestyle, very few studies have focused on this issue thus far. Therefo...

    Ye Fan, Jian-Jun Huang, Chen-Ming Sun, Nan Qiao, Hai-Xia Zhang, Hui Wang, Ran Tao, Ya-Nan Shen and Tong Wang

    Lipids in Health and Disease 2017 16:161

    Published on: 23 August 2017

  15. Research

    Significant decrease of saturation index in erythrocytes membrane from subjects with non-alcoholic fatty liver disease (NAFLD)

    The lipidomic profiling of erythrocyte membranes is expected to provide a peculiar scenario at molecular level of metabolic and nutritional pathways which may influence the lipid balance and the adaptation and...

    Maria Notarnicola, Maria Gabriella Caruso, Valeria Tutino, Caterina Bonfiglio, Raffaele Cozzolongo, Vito Giannuzzi, Valentina De Nunzio, Giampiero De Leonardis, Daniela I. Abbrescia, Isabella Franco, Vincenza Intini, Antonella Mirizzi and Alberto R. Osella

    Lipids in Health and Disease 2017 16:160

    Published on: 23 August 2017

  16. Research

    Lipases and lipid droplet-associated protein expression in subcutaneous white adipose tissue of cachectic patients with cancer

    Cancer cachexia is a multifactorial metabolic syndrome characterized by marked loss of adipose tissue and skeletal muscle. Fat loss from adipose tissue in cancer cachexia is partly the result of increased lipo...

    Renata Silvério, Fábio S. Lira, Lila M. Oyama, Cláudia M. Oller do Nascimento, José P. Otoch, Paulo S. M. Alcântara, Miguel L. Batista Jr and Marília Seelaender

    Lipids in Health and Disease 2017 16:159

    Published on: 22 August 2017

  17. Research

    Prediction of future cardiovascular disease with an equation to estimate apolipoprotein B in patients with high cardiovascular risk: an analysis from the TNT and IDEAL study

    Apolipoprotein B (apoB) is known to be a more powerful predictor of cardiovascular disease than conventional lipids. We aimed to determine the clinical relevance of a newly developed equation to estimate serum...

    You-Cheol Hwang, Hong-Yup Ahn, Ki Hoon Han, Sung-Woo Park and Cheol-Young Park

    Lipids in Health and Disease 2017 16:158

    Published on: 22 August 2017

  18. Research

    VDR Gene variation and insulin resistance related diseases

    Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed v...

    Fei-fei Han, Ya-li Lv, Li-li Gong, He Liu, Zi-rui Wan and Li-hong Liu

    Lipids in Health and Disease 2017 16:157

    Published on: 19 August 2017

  19. Research

    Differential expression of osteopontin, and osteoprotegerin mRNA in epicardial adipose tissue between patients with severe coronary artery disease and aortic valvular stenosis: association with HDL subclasses

    Previous studies suggest a relationship of the epicardial adipose tissue (EAT) with progression and calcification of the atherosclerotic plaque; however, it is unknown if this tissue expresses genes that may p...

    María Luna-Luna, David Cruz-Robles, Nydia Ávila-Vanzzini, Valentín Herrera-Alarcón, Jesús Martínez-Reding, Sergio Criales-Vera, Julio Sandoval-Zárate, Jesús Vargas-Barrón, Carlos Martínez-Sánchez, Armando Roberto Tovar-Palacio, José Manuel Fragoso, Elizabeth Carreón-Torres, Gilberto Vargas-Alarcón and Óscar Pérez-Méndez

    Lipids in Health and Disease 2017 16:156

    Published on: 18 August 2017

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