Reduction in mouse ear edema following addition of P. nagi ME P. nagi ME or oil (20 wt% in acetone) was applied topically once daily for 5 d, and edema measured 6 h after 20:4n-6 addition. Indomethacin was used as a positive control. A control methyl ester mix did not reduce edema (not shown in figure). Values represent mean of 5 replicates. Error bars represent 1 SD. AA, arachidonic acid.