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Table 1 Body weight, fasting plasma glucose and lipid metabolites in Chinese Bama minipigs

From: Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs

Parameters Baseline 1 month 2 months 3 months 4 months 5 months
Body weight (kg)       
CD 6.04 ± 1.24 9.22 ± 1.29 10.28 ± 1.51 12.34 ± 1.73 14.35 ± 2.14 16.85 ± 3.74
HSFD 6.04 ± 2.12 8.90 ± 2.68 10.76 ± 2.61 14.18 ± 4.25 18.50 ± 5.31 * 23.55 ± 7.46 **
HSFD+Ibrolipim 6.02 ± 1.10 8.48 ± 1.65 10.08 ± 1.84 13.02 ± 2.50 14.40 ± 2.51 # 16.56 ± 3.83 ##
Glucose (mmol/l)       
CD 4.71 ± 0.39 4.24 ± 0.90 4.83 ± 0.87 5.24 ± 1.00 4.65 ± 0.71 4.77 ± 0.57
HSFD 5.12 ± 0.84 5.97 ± 0.73 * 6.88 ± 0.57 * 8.89 ± 2.05 ** 9.54 ± 2.12 ** 10.27 ± 2.25 **
HSFD+Ibrolipim 4.78 ± 0.62 4.41 ± 1.45 4.96 ± 1.09 # 5.89 ± 0.50 # 4.85 ± 1.10 ## 4.75 ± 0.45 ##
Insulin (U/l)       
CD 6.97 ± 0.33 7.31 ± 0.94 7.50 ± 0.93 8.68 ± 0.82 7.25 ± 0.80 7.65 ± 1.33
HSFD 7.47 ± 1.16 9.12 ± 1.63 15.12 ± 3.22 * 21.16 ± 5.08 * 24.43 ± 3.55 ** 17.43 ± 3.80 **
HSFD+Ibrolipim 7.65 ± 0.91 8.73 ± 1.52 9.43 ± 0.84 # 10.95 ± 2.95 # 10.30 ± 3.57 ## 10.34 ± 2.71 #
Homeostatic model assessment       
CD 1.38 ± 0.18 1.54 ± 0.50 1.63 ± 0.47 1.97 ± 0.63 1.51 ± 0.32 1.64 ± 0.45
HSFD 1.59 ± 0.26 2.29 ± 0.39 4.38 ± 1.05 ** 7.04 ± 1.05 ** 10.40 ± 1.75 ** 7.83 ± 1.63 **
HSFD+Ibrolipim 1.56 ± 0.26 1.87 ± 0.56 2.11 ± 0.59 ## 2.89 ± 0.51 ## 2.16 ± 0.45 ## 2.62 ± 0.70 ##
Triglyceride (mmol/l)       
CD 0.59 ± 0.04 0.59 ± 0.06 0.63 ± 0.10 0.69 ± 0.16 0.71 ± 0.15 0.73 ± 0.13
HSFD 0.59 ± 0.05 0.94 ± 0.07 ** 1.50 ± 0.18 ** 1.87 ± 0.14 ** 2.03 ± 0.42 ** 2.10 ± 0.32 **
HSFD+Ibrolipim 0.58 ± 0.04 0.60 ± 0.01 # 0.78 ± 0.08 ## 0.87 ± 0.17 ## 1.03 ± 0.25 ## 1.10 ± 0.35 ##
Total cholesterol (mmol/l)       
CD 2.06 ± 0.34 1.99 ± 0.33 2.01 ± 0.35 1.68 ± 0.21 1.82 ± 0.49 2.07 ± 0.46
HSFD 2.31 ± 0.44 6.24 ± 1.77 ** 9.06 ± 1.44 ** 11.20 ± 2.02 ** 15.23 ± 2.00 ** 20.45 ± 2.83 **
HSFD+Ibrolipim 2.29 ± 0.55 8.02 ± 2.15 # 11.99 ± 2.15 # 13.55 ± 3.12 # 16.39 ± 4.23 22.14 ± 4.59
HDL cholesterol (mmol/l)       
CD 0.78 ± 0.14 0.76 ± 0.18 0.85 ± 0.17 1.02 ± 0.12 0.81 ± 0.16 0.96 ± 0.29
HSFD 0.89 ± 0.12 1.09 ± 0.18 * 1.37 ± 0.28 * 1.82 ± 0.53 * 2.00 ± 0.39 ** 1.83 ± 0.36 **
HSFD+Ibrolipim 0.79 ± 0.15 1.23 ± 0.21 2.29 ± 0.43 ## 2.85 ± 0.47 ## 2.92 ± 0.54 ## 2.86 ± 0.46 ##
  1. Values are means ± SD, n = 5 in each group; * P < 0.05, ** P < 0.01 vs. CD group; # P < 0.05, ## P < 0.01 vs. HSFD group.