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Table 2 SNP's associated (P < 0.01) with stable MetS features among subjects of the Doetinchem Cohort over 2 surveys (1993-1997; 1998-2002)

From: Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

SNP MAF Gene PR/allele (95%CI) P-Value
Hyperglycemia (n = 2280)    
rs1137101 0.46 LEPR 0.84 (0.76; 0.93) 0.001
rs3842748 0.21 INS-IGF2 1.20 (1.07; 1.35) 0.002
rs6795441 0.45 RAF1 0.86 (0.77; 0.95) 0.003
rs7903146 0.29 TCF7L2 1.17 (1.05; 1.30) 0.005
rs1143634 0.24 IL1B 1.17 (1.05; 1.31) 0.005
Abdominal obesity (n = 2931)   
rs35724 0.38 NR1H4 0.91 (0.85; 0.97) 0.005
rs10860603 0.14 NR1H4 0.86 (0.78; 0.96) 0.006
rs1800796 0.04 IL6 0.77 (0.64;0.93) 0.007
rs5882 0.31 CETP 0.90 (0.83;0.97) 0.007
rs429358 0.16 APOE 1.12 (1.03;1.23) 0.007
Hypertension (n = 2643)    
rs130005 0.10 CREBBP 0.89 (0.82; 0.97) 0.006
rs3759324 0.25 SCCN1A 1.07 (1.02; 1.12) 0.009
Low HDL-Cholesterol (n = 2959)   
rs1800777 0.03 CETP 1.60 (1.56;2.32) 3.3 E-12
rs3208305 0.30 LPL 0.70 (0.63;0.79) 9.3 E-10
rs328 0.11 LPL 0.60 (0.49; 0.72) 1.2 E-7
rs5882 0.31 CETP 0.76 (0.69;0.86) 2.1 E-6
rs429358 0.16 APOE 1.21 (1.07;1.37) 0.001
rs174546 0.33 FADS1 1.18 (1.07;1.30) 0.001
rs780094 0.36 GCKR 1.17 (1.06; 1.29) 0.002
rs268 0.02 LPL 1.45 (1.12; 1.86) 0.004
rs5275 0.31 PTGS2 1.15 (1.04; 1.27) 0.006
  1. MAF = Minor allele frequency; PR = Prevalence Ratio; b Prevalence ratios are expressed per minor allele assuming an additive genetic model