Table 2 SNP's associated (P < 0.01) with stable MetS features among subjects of the Doetinchem Cohort over 2 surveys (1993-1997; 1998-2002)

Hyperglycemia (n = 2280)

rs1137101

0.46

LEPR

0.84 (0.76; 0.93)

0.001

rs3842748

0.21

INS-IGF2

1.20 (1.07; 1.35)

0.002

rs6795441

0.45

RAF1

0.86 (0.77; 0.95)

0.003

rs7903146

0.29

TCF7L2

1.17 (1.05; 1.30)

0.005

rs1143634

0.24

IL1B

1.17 (1.05; 1.31)

0.005

Abdominal obesity (n = 2931)

rs35724

0.38

NR1H4

0.91 (0.85; 0.97)

0.005

rs10860603

0.14

NR1H4

0.86 (0.78; 0.96)

0.006

rs1800796

0.04

IL6

0.77 (0.64;0.93)

0.007

rs5882

0.31

CETP

0.90 (0.83;0.97)

0.007

rs429358

0.16

APOE

1.12 (1.03;1.23)

0.007

Hypertension (n = 2643)

rs130005

0.10

CREBBP

0.89 (0.82; 0.97)

0.006

rs3759324

0.25

SCCN1A

1.07 (1.02; 1.12)

0.009

Low HDL-Cholesterol (n = 2959)

rs1800777

0.03

CETP

1.60 (1.56;2.32)

3.3 E-12

rs3208305

0.30

LPL

0.70 (0.63;0.79)

9.3 E-10

rs328

0.11

LPL

0.60 (0.49; 0.72)

1.2 E-7

rs5882

0.31

CETP

0.76 (0.69;0.86)

2.1 E-6

rs429358

0.16

APOE

1.21 (1.07;1.37)

0.001

rs174546

0.33

FADS1

1.18 (1.07;1.30)

0.001

rs780094

0.36

GCKR

1.17 (1.06; 1.29)

0.002

rs268

0.02

LPL

1.45 (1.12; 1.86)

0.004

rs5275

0.31

PTGS2

1.15 (1.04; 1.27)

0.006