Effects of TO901317 treatment on the secretion and expression of apolipoproteins. (A-C) S-Hep and M-Hep were incubated with different concentration of TO901317, and the levels of apoipoproteins secreted in the medium were analyzed. Panel A, B and C represented apoB, apoA-I and apoE levels, respectively. (D, E) S-Hep were incubated with different concentration of TO901317, and mRNA levels of apoE (D) and ABCA1 (E) were analyzed. Data are mean ± SEM (n = 4). X-axes represent the concentration of TO901317. *: P < 0.01 compared with 0 μM, †: P < 0.05 with 0 μM, ‡: P < 0.01 with 0 and 0.02 μM, #: P < 0.03 with 0 and 0.02 μM.