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Table 1 Tissue concentration of amphotericin B (Mean ± SEM; ng/g) in mice 12 hours following the completion of twice-daily × 5 days treatment course of different doses of oral tropically stable formulation of AmB (iCo-010) or 12 hours following the completion of once daily × 5 days IV treatment course of Fungizone® 2 mg/kg

From: Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

  iCo-010 20 mg/kg BID for 5 days, n = 7a iCo-010 10 mg/kg BID for 5 days, n = 6b iCo-010 5 mg/kg BID for 5 days, n = 6c iCo-010 2.5 mg/kg BID for 5 days, n = 6b Fungizone® 2 mg/kg QD for 5 days, n = 6d
Plasma 538 ± 27 418 ± 48 232 ± 22 172 ± 10 791 ± 90
Liver 3494 ± 287 2543 ± 510 836 ± 97 446 ± 44 49794 ± 6993
Spleen 1939 ± 87 1407 ± 120 916 ± 121 342 ± 20 27008 ± 2400
Lung 3179 ± 312 2014 ± 185 1168 ± 307 408 ± 47 7533 ± 1299
Kidney 3685 ± 334 2268 ± 220 813 ± 89 495 ± 31 9100 ± 1140
Heart 366 ± 31 338 ± 41 156 ± 10 84 ± 8 1139 ± 243
Brain 169 ± 6 157 ± 3 112 ± 10 59 ± 5 234 ± 23
Skin 393 ± 45 165 ± 19 116 ± 20 BLQ 420 ± 269
Muscle 26 ± 16 24 ± 8 BLQ BLQ 468 ± 148
Visceral Fat 2114 ± 512 904 ± 220 471 ± 112 BLQ 3324 ± 654
  1. aAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.01), lung (p < 0.01) and fat tissue (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
  2. bAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.01) and lung (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
  3. cAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.05) and lung (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
  4. dAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01) and spleen (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).