Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

Table 1 Tissue concentration of amphotericin B (Mean ± SEM; ng/g) in mice 12 hours following the completion of twice-daily × 5 days treatment course of different doses of oral tropically stable formulation of AmB (iCo-010) or 12 hours following the completion of once daily × 5 days IV treatment course of Fungizone^® 2 mg/kg

	iCo-010 20 mg/kg BID for 5 days, n = 7^a	iCo-010 10 mg/kg BID for 5 days, n = 6^b	iCo-010 5 mg/kg BID for 5 days, n = 6^c	iCo-010 2.5 mg/kg BID for 5 days, n = 6^b	Fungizone^® 2 mg/kg QD for 5 days, n = 6^d
Plasma	538 ± 27	418 ± 48	232 ± 22	172 ± 10	791 ± 90
Liver	3494 ± 287	2543 ± 510	836 ± 97	446 ± 44	49794 ± 6993
Spleen	1939 ± 87	1407 ± 120	916 ± 121	342 ± 20	27008 ± 2400
Lung	3179 ± 312	2014 ± 185	1168 ± 307	408 ± 47	7533 ± 1299
Kidney	3685 ± 334	2268 ± 220	813 ± 89	495 ± 31	9100 ± 1140
Heart	366 ± 31	338 ± 41	156 ± 10	84 ± 8	1139 ± 243
Brain	169 ± 6	157 ± 3	112 ± 10	59 ± 5	234 ± 23
Skin	393 ± 45	165 ± 19	116 ± 20	BLQ	420 ± 269
Muscle	26 ± 16	24 ± 8	BLQ	BLQ	468 ± 148
Visceral Fat	2114 ± 512	904 ± 220	471 ± 112	BLQ	3324 ± 654

^aAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.01), lung (p < 0.01) and fat tissue (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
^bAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.01) and lung (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
^cAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01), spleen (p < 0.01), kidney (p < 0.05) and lung (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).
^dAmB concentration in plasma is statistically significantly different from concentration in liver (p < 0.01) and spleen (p < 0.01) within the same treatment group (One-way ANOVA followed by Dunnett Multiple Comparisons Test).

ISSN: 1476-511X