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Table 3 The ApoA1/C3/A5 genotypes and serum lipid levels between males and females

From: Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels

SNP

Genotype

n

TC

(mmol/L)

TG

(mmol/L)

HDL-C

(mmol/L)

LDL-C

(mmol/L)

ApoA1

(g/L)

ApoB

(g/L)

ApoA1/

ApoB

ApoA1 -75bp G>A

Male

        

(rs1799837)

GG

192

4.57 ± 1.06

0.92(0.46)

2.02 ± 0.46

2.40 ± 0.72

1.42 ± 0.18

0.90 ± 0.22

1.67 ± 0.44

 

GA

242

4.67 ± 1.03

1.05(0.70)

2.06 ± 0.54

2.32 ± 0.79

1.45 ± 0.16

0.89 ± 0.23

1.73 ± 0.52

 

AA

58

4.51 ± 0.66

0.78(0.54)

1.94 ± 0.37

2.43 ± 0.53

1.41 ± 0.14

0.89 ± 0.21

1.77 ± 1.04

 

F

-

0.867

11.673

1.458

0.894

2.408

0.117

0.914

 

P

-

0.421

0.003

0.234

0.410

0.091

0.890

0.402

 

Female

        
 

GG

210

4.73 ± 0.86

0.99(0.62)

2.15 ± 0.51

2.39 ± 0.65

1.46 ± 0.13

0.90 ± 0.21

1.74 ± 0.56

 

GA

264

4.68 ± 0.92

0.96(0.59)

2.06 ± 0.42

2.48 ± 0.66

1.45 ± 0.14

0.93 ± 0.20

1.61 ± 0.35

 

AA

64

4.61 ± 0.94

0.96(0.59)

2.01 ± 0.47

2.43 ± 0.69

1.42 ± 0.13

0.93 ± 0.21

1.60 ± 0.34

 

F

-

0.477

0.236

3.273

1.094

2.153

1.369

5.689

 

P

-

0.621

0.889

0.039

0.336

0.117

0.255

0.004

ApoC3 3238C>G

Male

        

(rs5128)

CC

252

4.57 ± 0.96

0.93(0.65)

1.97 ± 0.45

2.34 ± 0.76

1.42 ± 0.15

0.88 ± 0.23

1.75 ± 0.69

 

CG

192

4.61 ± 1.02

1.00(0.50)

2.11 ± 0.57b

2.35 ± 0.66

1.44 ± 0.19

0.89 ± 0.20

1.68 ± 0.42

 

GG

48

4.85 ± 1.21

1.02(0.60)

2.07 ± 0.36

2.57 ± 0.90

1.45 ± 0.15

0.96 ± 0.27

1.64 ± 0.46

 

F

-

1.551

2.954

4.528

2.036

1.138

2.601

1.213

 

P

-

0.213

0.228

0.011

0.132

0.321

0.075

0.298

 

Female

        
 

CC

216

4.65 ± 0.80

0.92(0.60)

2.08 ± 0.42

2.45 ± 0.62

1.45 ± 0.12

0.91 ± 0.17

1.64 ± 0.31

 

CG

264

4.67 ± 0.98

0.98(0.64)

2.10 ± 0.48

2.41 ± 0.68

1.44 ± 0.14

0.92 ± 0.21

1.67 ± 0.46

 

GG

58

4.93 ± 0.87

1.02(1.00)

2.05 ± 0.53

2.56 ± 0.72

1.45 ± 0.12

0.95 ± 0.25

1.68 ± 0.73

 

F

-

2.342

15.113

0.314

1.249

0.403

0.920

0.339

 

P

-

0.097

0.001

0.731

0.288

0.668

0.399

0.712

ApoA5 -1131T>C

Male

        

(rs662799)

TT

268

4.56 ± 1.01

0.91(0.53)

2.04 ± 0.48

2.33 ± 0.76

1.43 ± 0.15

0.88 ± 0.22

1.76 ± 0.68

 

TC

178

4.58 ± 1.01

1.03(0.66)

1.99 ± 0.49

2.34 ± 0.70

1.42 ± 0.19

0.90 ± 0.22

1.67 ± 0.42

 

CC

46

5.08 ± 0.90

1.14(0.72)

2.15 ± 0.56

2.66 ± 0.67

1.47 ± 0.12

0.99 ± 0.22

1.57 ± 0.42

 

F

-

7.637

13.443

0.535

4.492

0.135

8.091

7.797

 

P

-

0.001

0.001

0.586

0.012

0.873

0.000

0.000

 

Female

        
 

TT

266

4.60 ± 0.84

0.89(0.58)

2.09 ± 0.42

2.39 ± 0.66

1.44 ± 0.13

0.90 ± 0.19

1.69 ± 0.38

 

TC

226

4.77 ± 0.99

1.04(0.64)

2.10 ± 0.52

2.49 ± 0.67

1.45 ± 0.14

0.95 ± 0.20

1.61 ± 0.41

 

CC

46

4.79 ± 0.77

1.01(1.04)

2.03 ± 0.45

2.48 ± 0.64

1.45 ± 0.12

0.93 ± 0.25

1.74 ± 0.78

 

F

-

1.662

16.015

0.272

1.233

0.333

2.154

0.278

 

P

-

0.191

0.000

0.762

0.292

0.717

0.117

0.758

ApoA5 c.553G>T

Male

        

(rs2075291)

GG

466

4.61 ± 1.02

0.93(0.56)

2.05 ± 0.50

2.36 ± 0.74

1.43 ± 0.16

0.89 ± 0.22

1.72 ± 0.58

 

GT

26

4.64 ± 0.87

1.63(1.39)

1.74 ± 0.33

2.38 ± 0.75

1.39 ± 0.18

0.96 ± 0.27

1.62 ± 0.67

 

F

-

0.147

4.108

3.122

0.134

1.232

1.559

0.848

 

P

-

0.883

0.000

0.002

0.893

0.218

0.120

0.397

 

Female

        
 

GG

496

4.70 ± 0.91

0.98(0.60)

2.10 ± 0.47

2.44 ± 0.66

1.45 ± 0.14

0.92 ± 0.20

1.66 ± 0.45

 

GT

42

4.60 ± 0.82

0.97(0.74)

1.97 ± 0.33

2.39 ± 0.61

1.45 ± 0.09

0.95 ± 0.21

1.60 ± 0.35

 

F

-

0.689

0.844

2.359

0.474

0.000

0.930

0.843

 

P

-

0.491

0.399

0.018

0.636

1.000

0.353

0.399

ApoA5 c.457G>A

Male

        

(rs3135507)

GG

424

4.63 ± 0.96

1.00(0.58)

2.07 ± 0.49

2.38 ± 0.74

1.44 ± 0.15

0.90 ± 0.22

1.72 ± 0.59

 

GA/AA

68

4.51 ± 1.26

1.01(0.63)

1.79 ± 0.43

2.30 ± 0.73

1.36 ± 0.22

0.88 ± 0.22

1.64 ± 0.50

 

F

-

0.913

-0.268

4.445

0.829

3.795

0.696

1.059

 

P

-

0.362

0.788

0.000

0.407

0.000

0.487

0.290

 

Female

        
 

GG

484

4.72 ± 0.91

0.98(0.59)

2.09 ± 0.47

2.47 ± 0.66

1.45 ± 0.14

0.93 ± 0.20

1.64 ± 0.43

 

GA/AA

54

4.40 ± 0.81

0.94(0.45)

2.06 ± 0.38

2.21 ± 0.65

1.43 ± 0.10

0.84 ± 0.20

1.82 ± 0.52

 

F

-

2.477

0.589

0.453

2.750

1.021

3.137

2.452

 

P

-

0.014

0.556

0.651

0.006

0.309

0.002

0.014

  1. SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The values of TG were presented as median (interquartile range). The difference among the genotypes was determined by the Kruskal-Wallis test or the Wilcoxon-Mann-Whitney test.
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Lipids in Health and Disease

ISSN: 1476-511X