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Table 2 Mean NMR lipoprotein particle size and number in men stratified by baseline triglyceride status.

From: High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study

 

Normal Triglycerides

Hyper-Triglyceridemic

p-values

 

0 Hr

3.5 Hr

6 Hr

0 Hr

3.5 Hr

6 Hr

Triglyceride Status

Time

Triglyceride status × time

LDL particle No., nmol/L

1213 (22)

1187 (22)

1196 (22)

1609 (26)

1592 (26)

1601 (27)

< 0.0001

< 0.0001

0.5231

IDL particles, nmol/L

28 (2)

44 (3)

43 (3)

56 (3)

84 (4)

75 (3)

< 0.0001

< 0.0001

0.0002

Large LDL particles, nmol/L

406 (11)

421 (12)

452 (12)

266 (14)

308 (14)

329 (14)

< 0.0001

< 0.0001

0.0011

Small LDL particles, nmol/L

788 (21)

726 (21)

704 (22)

1268 (26)

1171 (26)

1175 (27)

< 0.0001

< 0.0001

0.0168

LDL particle size, nm

21 (0.03)

21 (0.03)

21 (0.03)

20 (0.04)

20 (0.04)

20 (0.04)

< 0.0001

< 0.0001

0.0012

HDL particle No., μmol/L

30 (0.3)

30 (0.3)

31 (0.3)

29 (0.4)

29 (0.3)

30 (0.3)

0.0034

< 0.0001

0.0157

Large HDL particles, μmol/L

5 (0.1)

5 (0.1)

5 (0.2)

3 (0.2)

3 (0.2)

3 (0.2)

< 0.0001

< 0.0001

0.0001

Medium HDL particles, μmol/L

3 (0.2)

5 (0.2)

7 (0.2)

2 (0.2)

4 (0.3)

5 (0.3)

< 0.0001

< 0.0001

0.0579

Small HDL particles, μmol/L

21 (0.3)

19 (0.3)

18 (0.3)

24 (0.4)

22 (0.4)

21 (0.4)

< 0.0001

< 0.0001

< 0.0001

HDL particle size, nm

9 (0.02)

9 (0.02)

9 (0.02)

8 (0.02)

8 (0.03)

9 (0.02)

< 0.0001

< 0.0001

< 0.0001

VLDL particle No., nmol/L

48 (2)

49 (2)

42 (2)

100 (2)

87 (2)

83 (2)

< 0.0001

< 0.0001

< 0.0001

Large VLDL particles, nmol/L

1 (0.2)

3 (0.2)

3 (0.3)

6 (0.2)

10 (0.3)

10 (0.3)

< 0.0001

< 0.0001

< 0.0001

Medium VLDL particles, nmol/L

19 (1)

28 (1)

18 (1)

55 (2)

56 (2)

48 (1)

< 0.0001

< 0.0001

< 0.0001

Small VLDL particles, nmol/L

26 (0.9)

15 (0.7)

19 (0.8)

36 (1)

18 (0.9)

24 (1)

< 0.0001

< 0.0001

< 0.0001

Chylomicrons, nmol/L

0.04 (0.01)

0.3 (0.01)

0.2 (0.02)

0.04 (0.01)

0.6 (0.02)

0.5 (0.02)

< 0.0001

< 0.0001

< 0.0001

VLDL particle size, nm

51 (0.4)

53 (0.4)

58 (0.5)

53 (0.5)

58 (0.5)

60 (0.6)

< 0.0001

< 0.0001

< 0.0001

  1. Adjustment variables include field center, age, waist circumference, smoker, diabetes.
  2. HDL = high-density lipoprotein; IDL = intermediate-density lipoprotein; LDL = low-density lipoprotein; NMR = nuclear magnetic resonance spectroscopy; VLDL = very low-density lipoprotein.
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Lipids in Health and Disease

ISSN: 1476-511X