Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin

Table 4 Influence of APOE genotypes on basal serum lipids in normolipidemic individuals by multiple linear regression analysis

Variable	ε2	p-value	ε3	p-value	ε4	p-value
	B (SE)		B (SE)		B (SE)
Total cholesterol	-11.6 (5.3)	0.030	-1.0 (3.3)	0.753	6.7 (3.3)	0.047
LDL cholesterol	-18.1 (5.2)	0.001	-0.7 (3.4)	0.847	8.8 (3.4)	0.010
HDL cholesterol	9.0 (3.4)	0.009	-1.2 (2.2)	0.568	-1.8 (2.2)	0.399
VLDL cholestrol	-1.8 (1.5)	0.236	0.8 (0.9)	0.352	-0.3 (0.9)	0.799
ApoB	-13.8 (6.9)	0.046	-2.6 (4.2)	0.534	9.0 (4.5)	0.047
ApoAI	11.3 (7.6)	0.138	0.7 (4.5)	0.879	-5.4 (4.9)	0.269

B and (SE) represent regression coefficient and standard error and are expressed in mg/dL. B values were obtained from multiple linear regression analysis introducing gender, ethnics, family history of coronary artery disease, age, hypertension, obesity, cigarette smoking, physical activity and alcohol consumption as covariates. HDL, high density lipoprotein; LDL, low density lipoprotein; VLDL, very low density lipoprotein; apoB, apolipoprotein B; apoAI, apolipotrotein AI. Conversion factors to convert to Systeme Internacional (SI) units are 0.02586 for cholesterol (mmol/l), 0.01129 for triglycerides (mmol/l) and 0.01 for apolipoproteins (g/l).

ISSN: 1476-511X