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Table 4 Detailed listing of concomitant medications and patient characteristics for the 3 patients with HDL-C reductions ≤30% at study endpoint

From: Low incidence of paradoxical reductions in HDL-C levels in dyslipidemic patients treated with fenofibrate alone or in combination with ezetimibe or ezetimibe/simvastatin

     

HDL-C (mmol/L)

Triglycerides (mmol/L)

Apo AI (g/L)

Treatment

Concomitant Therapy

Age

(yr)

Sex

BMI

Baseline

Endpoint

(% change)

Baseline

Endpoint

(% change)

Baseline

Endpoint

(% change)

Reduction between 30%-40%

Feno

None

36

Male

<30

1.04

0.73

(-30.00)

3.48

3.59

(3.25)

1.26

1.23

(-2.38)

Reduction between >40%-50%

EZE+Feno

celecoxib

43

Female

<30

0.85

0.44

(-48.48)

3.44

2.25

(-34.65)

1.18

0.53

(-55.1)

 

acetaminophen

         
 

clonazepam

         
 

chlorthalidone

         
 

propanolol HCl

         

Reduction over 50%

Feno

acetaminophen acetylcysteine

52

Male

<30

1.07

0.47

(-56.63)

1.94

3.27

(68.02)

1.47

0.54

(-63.3)

 

cetrimide+naphazoline nitrate+phenylephrine hydrochloride+prednisolone

         
 

fenspiride hydrochloride

         
 

bacitracin zinc + tixocortol pivalate

         
 

oxomemazine

         
 

ibuprofen

         
 

telithromycin

         
 

guaifenesin+oxomemazine+sodium benzoate

         
 

allopurinol

         
 

niaouli oil+quinine benzoate+thiamine HCl

         
 

losartan potassium

         
  1. BMI = body mass index; EZE = ezetimibe; Feno = fenofibrate