Figure 2
From: Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
Histological evaluation in kidneys of young and adult C57 and ApoE mice. A: the mesangial expansion was evaluated through the percentage of periodic acid-Schiff staining (PAS) in the glomerulus and B: tubulointersticial fibrosis was evaluated by the percentage of Masson's Trichrome staining in the tubular area in young (2-month-old) and adult (8-month-old) C57BL/6 (C57) and apolipoprotein E-deficient (ApoE) mice. C. Typical photomicrograhies showing the increase in mesangial matrix (upper panel, 40 × magnification) and collagen deposition (lower panel, 20 × magnification) in ApoE mice. Values indicate means ± SEM of the number of animals in parentheses. *p < 0.05 and **p < 0.01 vs C57 and †p < 0.05 vs 2-month-old (2-way ANOVA).