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Table 1 Effects of saline, rHDL and ETC-642 infusions on plasma lipid levels in NZW rabbits

From: The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

 

BASELINE

TIME OF SACRIFICE

 

TC

(mM/L)

HDL-C

(mM/L)

Non HDL-C

(mM/L)

TC

(mM/L)

HDL-C

(mM/L)

Non HDL-C

(mM/L)

SALINE

0.86 ± 0.07

0.77 ± 0.09

0.09 ± 0.07

2.64 ± 0.29*

0.65 ± 0.03

1.99 ± 0.28*

rHDL

0.84 ± 0.06

0.63 ± 0.06

0.21 ± 0.06

2.53 ± 0.49*

0.66 ± 0.06

1.87 ± 0.46*

ETC-642

0.99 ± 0.05

0.73 ± 0.04

0.26 ± 0.06

2.87 ± 0.27*

0.61 ± 0.05

2.25 ± 0.26*

  1. NZW rabbits (n = 10/group) were maintained on a diet of chow supplemented with 0.2% (w/w) cholesterol for 6 weeks On days 3 and 5 of the last week of dietary supplementation the animals received two infusions of saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide). Blood samples were collected at baseline and at sacrifice and plasma lipid levels were measured as described in "Materials and Methods". Results are expressed as mean ± SEM. * p < 0.05 compared to baseline.
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Lipids in Health and Disease

ISSN: 1476-511X