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Table 1 Effects of saline, rHDL and ETC-642 infusions on plasma lipid levels in NZW rabbits

From: The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

  BASELINE TIME OF SACRIFICE
  TC
(mM/L)
HDL-C
(mM/L)
Non HDL-C
(mM/L)
TC
(mM/L)
HDL-C
(mM/L)
Non HDL-C
(mM/L)
SALINE 0.86 ± 0.07 0.77 ± 0.09 0.09 ± 0.07 2.64 ± 0.29* 0.65 ± 0.03 1.99 ± 0.28*
rHDL 0.84 ± 0.06 0.63 ± 0.06 0.21 ± 0.06 2.53 ± 0.49* 0.66 ± 0.06 1.87 ± 0.46*
ETC-642 0.99 ± 0.05 0.73 ± 0.04 0.26 ± 0.06 2.87 ± 0.27* 0.61 ± 0.05 2.25 ± 0.26*
  1. NZW rabbits (n = 10/group) were maintained on a diet of chow supplemented with 0.2% (w/w) cholesterol for 6 weeks On days 3 and 5 of the last week of dietary supplementation the animals received two infusions of saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide). Blood samples were collected at baseline and at sacrifice and plasma lipid levels were measured as described in "Materials and Methods". Results are expressed as mean ± SEM. * p < 0.05 compared to baseline.