Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations

Yan, Ting-Ting; Yin, Rui-Xing; Li, Qing; Huang, Ping; Zeng, Xiao-Na; Huang, Ke-Ke; Aung, Lynn Htet Htet; Wu, Dong-Feng; Liu, Cheng-Wu; Pan, Shang-Ling

doi:10.1186/1476-511X-10-248

Lipids in Health and Disease

Table 5 Correlation between environmental factors and serum lipid parameters in the Mulao and Han populations

From: Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations

Lipid parameter	Relative factor	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
Mulao plus Han
TC	Body mass index	0.053	0.010	0.145	5.530	0.000
	Age	0.012	0.002	0.155	5.960	0.000
	Alcohol consumption	0.177	0.040	0.113	4.379	0.000
	Diastolic blood pressure	0.006	0.003	0.054	2.004	0.045
TG	Body mass index	0.107	0.016	0.170	6.582	0.000
	Gender	-0.309	0.127	-0.077	-2.445	0.015
	Alcohol consumption	0.214	0.085	0.079	2.509	0.012
	Blood glucose	0.080	0.032	0.063	2.464	0.014
HDL-C	Body mass index	-0.030	0.004	-0.191	-7.412	0.000
	Alcohol consumption	0.105	0.021	0.157	4.981	0.000
	Gender	0.105	0.031	0.105	3.348	0.001
	Age	0.002	0.001	0.058	2.261	0.024
LDL-C	Body mass index	0.051	0.007	0.186	7.334	0.000
	Age	0.010	0.002	0.174	6.673	0.000
	Blood glucose	0.030	0.014	0.054	2.082	0.038
ApoAI	Alcohol consumption	0.131	0.014	0.287	9.143	0.000
	Body mass index	-0.010	0.003	-0.090	-3.483	0.001
	Age	0.002	0.001	0.073	2.863	0.004
	Gender	0.061	0.021	0.089	2.850	0.004
	Nation	-0.045	0.017	-0.066	-2.586	0.010
ApoB	Body mass index	0.021	0.003	0.165	6.425	0.000
	Nation	0.121	0.021	0.147	5.768	0.000
	Blood glucose	0.024	0.007	0.092	3.611	0.000
	Gender	-0.075	0.021	-0.091	-3.537	0.000
	Pulse pressure	0.001	0.001	0.054	2.109	0.035
ApoAI/ApoB	Body mass index	-0.047	0.006	-0.197	-7.634	0.000
	Blood glucose	-0.036	0.013	-0.076	-2.904	0.004
	Gender	0.207	0.048	0.135	4.320	0.000
	Alcohol consumption	0.118	0.032	0.115	3.663	0.000
	Age	-0.003	0.001	-0.066	-2.526	0.012
	Nation	-0.087	0.039	-0.058	-2.247	0.025
Mulao
TC	Body mass index	0.066	0.016	0.153	4.163	0.000
	Age	0.011	0.003	0.126	3.455	0.001
	Alcohol consumption	0.179	0.061	0.108	2.953	0.003
TG	Body mass index	0.126	0.025	0.186	5.088	0.000
	Alcohol consumption	0.407	0.095	0.156	4.275	0.000
HDL-C	Body mass index	-0.037	0.006	-0.244	-6.727	0.000
	Alcohol consumption	0.066	0.021	0.113	3.115	0.002
LDL-C	Body mass index	0.054	0.011	0.182	4.997	0.000
	Age	0.009	0.002	0.146	3.998	0.000
ApoAI	Alcohol consumption	0.095	0.019	0.184	5.009	0.000
	Age	0.002	0.001	0.088	2.393	0.017
ApoB	Body mass index	0.026	0.007	0.142	3.830	0.000
	Gender	-0.087	0.040	-0.080	-2.16	0.031
ApoAI/ApoB	Body mass index	-0.041	0.012	-0.129	-3.468	0.001
	Blood glucose	-0.052	0.023	-0.084	-2.260	0.024
Han Chinese
TC	Diastolic blood pressure	0.014	0.003	0.147	3.981	0.000
	Age	0.012	0.002	0.180	5.005	0.000
	Body mass index	0.041	0.011	0.133	3.688	0.000
	Alcohol consumption	0.188	0.052	0.127	3.610	0.000
TG	Body mass index	0.082	0.022	0.138	3.744	0.000
	Blood glucose	0.151	0.043	0.125	3.500	0.000
	Gender	-0.474	0.144	-0.119	-3.301	0.001
	Diastolic blood pressure	0.017	0.006	0.094	2.560	0.011
HDL-C	Body mass index	-0.022	0.006	-0.141	-3.811	0.000
	Alcohol consumption	0.110	0.034	0.144	3.250	0.001
	Gender	0.228	0.054	0.213	4.196	0.000
	Cigarette smoking	0.122	0.046	0.123	2.640	0.008
LDL-C	Age	0.010	0.002	0.185	4.946	0.000
	Body mass index	0.047	0.009	0.182	5.052	0.000
	Blood glucose	0.050	0.019	0.094	2.624	0.009
	Diastolic blood pressure	0.006	0.003	0.074	1.992	0.047
ApoAI	Alcohol consumption	0.129	0.016	0.345	8.253	0.000
	Body mass index	-0.014	0.003	-0.175	-4.997	0.000
	Cigarette smoking	0.088	0.021	0.182	4.119	0.000
	Gender	0.099	0.025	0.189	3.942	0.000
ApoB	Body mass index	0.018	0.002	0.300	8.877	0.000
	Blood glucose	0.023	0.004	0.182	5.433	0.000
	Gender	-0.046	0.016	-0.112	-2.819	0.005
	Systolic blood pressure	0.001	0.000	0.093	2.446	0.015
	Age	0.001	0.001	0.104	2.802	0.005
	Alcohol consumption	0.026	0.012	0.089	2.230	0.026
ApoAI/ApoB	Body mass index	-0.050	0.005	-0.323	-9.364	0.000
	Age	-0.004	0.001	-0.112	-3.234	0.001
	Blood glucose	-0.026	0.011	-0.082	-2.347	0.019
	Gender	0.273	0.049	0.264	5.575	0.000
	Cigarette smoking	0.154	0.042	0.161	3.683	0.000
	Alcohol consumption	0.098	0.031	0.133	3.225	0.001

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B

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ISSN: 1476-511X

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