Table 1 Basic characteristics of patients and controls
Controls N = 174 | Familial hypercholesterolemia N = 546 | Value of P | |
|---|---|---|---|
Age (years) | 39.7 ± 17.5 | 43.5 ± 16.3 | 0.009 |
Women (%) | 55.7 | 47.3 | 0.62 |
BMI | 25.7 | 26.6 | 0.20 |
HT (%) | 10.3 | 12.7 | 0.41 |
DM (%) | 2.3 | 2.4 | 1.000 |
Total cholesterol (mg/dl) | 239.6 ± 70.3 | 270.3 ± 70.4 | < 0.001 |
Triglycerides (mg/dl) | 102.2 ± 61.1 | 109.1 ± 62.5 | 0.22 |
LDLc (mg/dl) | 168.4 ± 68.4 | 201.3 ± 67.1 | < 0.001 |
HDLc (mg/dl) | 50.2 ± 13.4 | 46.1 ± 13.2 | < 0.001 |
Xanthomas | 0.0 | 102 (18.6%) | < 0.001 |
Smoking (%) | 46.8 | 49.4 | 0.55 |
Lipid-lowering treatment | 66 (37.9%) | 458 (83.9%) | < 0.001 |
CV disease | 8 (4.6%) | 80 (14.7%) | < 0.001 |
First CV event (years) | 57.1 ± 13.3 | 46.7 ± 11.1 | 0.01 |
Coronary artery disease | 6 (3.4%) | 75 (13.7%) | < 0.001 |
Cerebrovascular disease | 3 (1.7%) | 4 (0.7%) | 0.37 |
Peripheral arterial disease | 1 (0.5%) | 12 (2.1%) | 0.21 |
CVD distribution: | |||
-single territory | 6 (3.5%) | 71 (13%) | < 0.001 |
-two or more territories | 2 (1.2%) | 9 (1.6%) |