Skip to main content

Table 1 Basic characteristics of patients and controls

From: R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study

  Controls N = 174 Familial hypercholesterolemia N = 546 Value of P
Age (years) 39.7 ± 17.5 43.5 ± 16.3 0.009
Women (%) 55.7 47.3 0.62
BMI 25.7 26.6 0.20
HT (%) 10.3 12.7 0.41
DM (%) 2.3 2.4 1.000
Total cholesterol (mg/dl) 239.6 ± 70.3 270.3 ± 70.4 < 0.001
Triglycerides (mg/dl) 102.2 ± 61.1 109.1 ± 62.5 0.22
LDLc (mg/dl) 168.4 ± 68.4 201.3 ± 67.1 < 0.001
HDLc (mg/dl) 50.2 ± 13.4 46.1 ± 13.2 < 0.001
Xanthomas 0.0 102 (18.6%) < 0.001
Smoking (%) 46.8 49.4 0.55
Lipid-lowering treatment 66 (37.9%) 458 (83.9%) < 0.001
CV disease 8 (4.6%) 80 (14.7%) < 0.001
First CV event (years) 57.1 ± 13.3 46.7 ± 11.1 0.01
Coronary artery disease 6 (3.4%) 75 (13.7%) < 0.001
Cerebrovascular disease 3 (1.7%) 4 (0.7%) 0.37
Peripheral arterial disease 1 (0.5%) 12 (2.1%) 0.21
CVD distribution:    
-single territory 6 (3.5%) 71 (13%) < 0.001
-two or more territories 2 (1.2%) 9 (1.6%)  
  1. Values expressed as means ± standard deviation. BMI: body mass index, calculated by dividing weight by height squared. HT: arterial hypertension. DM: diabetes mellitus. CV: cardiovascular. LDLc: low-density lipoproteins cholesterol. HDLc: high-density lipoproteins cholesterol.