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Table 3 Multivariate analysis of FH patients

From: R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study

   CVD Patients (%)     
  Patients
(n = 546)
No
(n = 466)
Yes
(n = 80)
OR (CI 95%)* P Adjusted OR** (CI 95%) P
FVII        
RR 410 350 (75.1) 60 (75.0) 1.00 (Reference)   1.00 (Reference)  
RQ 127 110 (23.6) 17 (21.3) 0.89 (0.50 - 1.59) 0.70 0.76 (0.36 - 1.58) 0.46
QQ 9 6 (1.3) 3 (3.7) 2.88 (0.70 -11.84) 0.14 3.53 (0.66 - 18.92) 0.14
RQ/QQ 136 116 (24.9) 20 (25.0) 0.99 (0.58 - 1.72) 0.98 0.89 (0.45 - 1.78) 0.75
   CAD Patients (%)     
  Patients
(n = 546)
No
(n = 471)
Yes
(n = 75)
OR (CI 95%)* P Adjusted OR** (CI 95%) P
FVII        
RR 410 354 (75.1) 56 (74.7) 1.00 (Reference)   1.00 (Reference)  
RQ 127 111 (23.5) 16 (21.3) 0.90 (0.50 - 1.63) 0.73 0.90 (0.43 - 1.87) 0.77
QQ 9 6 (1.4) 3 (4.0) 3.12 (0.76 -12.86) 0.11 3.33 (0.64 - 17.24) 0.15
RQ/QQ 136 117 (24.9) 19 (24.3) 1.02 (0.58 - 1.78) 0.96 1.05 (0.52 - 2.08) 0.90
   PAD Patients (%)     
  Patients
(n = 546)
No
(n = 534)
Yes
(n = 12)
OR (CI 95%)* P Adjusted OR** (CI 95%) P
FVII        
RR 410 401 (75.1) 9 (75.0) 1.00 (Reference)   1.00 (Reference)  
RQ 127 125 (23.4) 2 (13.7) 0.71 (0.15 -3.34) 0.67 0.78 (0.15 - 3.84) 0.76
QQ 9 8 (1.5) 1 (8.3) 5.56 (0.63 -49.33) 0.12 5.77 (0.26 - 125.96) 0.26
RQ/QQ 136 132 (24.9) 3 (24.0) 1.00 (0.27 - 3.77) 0.99 1.03 (0.26 - 4.17) 0.96
  1. *Crude OR obtained by univariate logistic regression analysis. **Multivariate logistic regression adjusted for sex, age, body mass index, xanthomas, arterial hypertension, smoking, diabetes mellitus, LDLc, HDLc and lipid-lowering treatment. FVII: Factor VII. FH: Heterozygous Familial Hypercholesterolemia. CVD: cardiovascular disease. CAD: coronary artery disease. PAD: peripheral artery disease.