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Table 3 Multivariate analysis of FH patients

From: R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study

  

CVD Patients (%)

    
 

Patients

(n = 546)

No

(n = 466)

Yes

(n = 80)

OR (CI 95%)*

P

Adjusted OR** (CI 95%)

P

FVII

       

RR

410

350 (75.1)

60 (75.0)

1.00 (Reference)

 

1.00 (Reference)

 

RQ

127

110 (23.6)

17 (21.3)

0.89 (0.50 - 1.59)

0.70

0.76 (0.36 - 1.58)

0.46

QQ

9

6 (1.3)

3 (3.7)

2.88 (0.70 -11.84)

0.14

3.53 (0.66 - 18.92)

0.14

RQ/QQ

136

116 (24.9)

20 (25.0)

0.99 (0.58 - 1.72)

0.98

0.89 (0.45 - 1.78)

0.75

  

CAD Patients (%)

    
 

Patients

(n = 546)

No

(n = 471)

Yes

(n = 75)

OR (CI 95%)*

P

Adjusted OR** (CI 95%)

P

FVII

       

RR

410

354 (75.1)

56 (74.7)

1.00 (Reference)

 

1.00 (Reference)

 

RQ

127

111 (23.5)

16 (21.3)

0.90 (0.50 - 1.63)

0.73

0.90 (0.43 - 1.87)

0.77

QQ

9

6 (1.4)

3 (4.0)

3.12 (0.76 -12.86)

0.11

3.33 (0.64 - 17.24)

0.15

RQ/QQ

136

117 (24.9)

19 (24.3)

1.02 (0.58 - 1.78)

0.96

1.05 (0.52 - 2.08)

0.90

  

PAD Patients (%)

    
 

Patients

(n = 546)

No

(n = 534)

Yes

(n = 12)

OR (CI 95%)*

P

Adjusted OR** (CI 95%)

P

FVII

       

RR

410

401 (75.1)

9 (75.0)

1.00 (Reference)

 

1.00 (Reference)

 

RQ

127

125 (23.4)

2 (13.7)

0.71 (0.15 -3.34)

0.67

0.78 (0.15 - 3.84)

0.76

QQ

9

8 (1.5)

1 (8.3)

5.56 (0.63 -49.33)

0.12

5.77 (0.26 - 125.96)

0.26

RQ/QQ

136

132 (24.9)

3 (24.0)

1.00 (0.27 - 3.77)

0.99

1.03 (0.26 - 4.17)

0.96

  1. *Crude OR obtained by univariate logistic regression analysis. **Multivariate logistic regression adjusted for sex, age, body mass index, xanthomas, arterial hypertension, smoking, diabetes mellitus, LDLc, HDLc and lipid-lowering treatment. FVII: Factor VII. FH: Heterozygous Familial Hypercholesterolemia. CVD: cardiovascular disease. CAD: coronary artery disease. PAD: peripheral artery disease.