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Table 6 Effect of agitational intensity on release of NP and MP from CF6 (n = 3)

From: Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

 

Cumulative % of release ± SEM

 

NP

MP

Time

(h)

100 RPM

50 RPM

150 RPM

100 RPM

50 RPM

150 RPM

0

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

2

8.50 ± 0.71

13.28 ± 0.68

14.50 ± 1.30

11.41 ± 2.31

15.31 ± 1.71

18.21 ± 1.35

4

27.35 ± 1.12

31.81 ± 1.23

34.21 ± 1.89

27.80 ± 2.44

31.71 ± 1.20

33.4 ± 2.5

6

38.46 ± 1.54

44.74 ± 1.50

47.41 ± 2.80

41.04 ± 2.09

45.66 ± 3.12

49.50 ± 1.51

8

55.92 ± 2.31

59.28 ± 1.91

62.53 ± 2.30

55.71 ± 2.61

59.41 ± 2.96

63.21 ± 2.97

10

65.13 ± 3.02

73.15 ± 0.21

77.08 ± 2.67

71.58 ± 3.42

75.27 ± 2.31

77.81 ± 2.46

12

83.53 ± 2.86

88.14 ± 1.10

91.73 ± 1.80

85.02 ± 3.79

89.13 ± 1.90

93.41 ± 1.83