Parameters | Control | HFD | HFD+G | HSD | HSD+G |
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Renal Catalase (U/gm)
| 4.4 ± 0.29a | 14.2 ± 1.3b | 8.3 ± 0.64c | 14.5 ± 0.34b | 9.8 ± 0.67c |
S. MDA (nmol/ml)
| 2.6 ± 0.22 a | 4.9 ± 0.31b | 2.4 ± 0.42a | 7.3 ± 0.37c | 4.1 ± 0.44b |
Renal MDA (nmol/g)
| 1.2 ± 0.15a | 6.6 ± 0.27b | 3.7 ± 0.41cd | 4.8. ± 0.5c | 2.7 ± 0.30 ad |
S. NO (μmol/L)
| 2.8 ± 0.28 a | 2.2 ± 0.14b | 3.7 ± 0.24ac | 1.6 ± 0.26 d | 6.8 ± 0.53 e |
Renal NO (μmol/g)
| 1.3 ± 0.09a | 0.7 ± 0.04b | 0.9 ± 0.025c | 0.6 ± 0.03b | 0.8 ± 0.02c |
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Each value is the mean ± SEM. Means have different superscript letters indicate significant variation at (P ≤ 0.05), while the same letters indicate non significant variation
- Feeding of HFD and HSD caused a significant increase in serum MDA level compared with control group. Treatment with Garcinia significantly decreased MDA level compared with those in group HFD and HSD. In renal tissues MDA level and catalase activity were significantly increased in HFD and HSD compared with control group and treatment with Garcinia ameliorated theses changes.
- Both serum and renal NO levels significantly lowered in HFD and HSD in comparison with control. Treatment with the Garcinia significantly elevated the No level in rats consuming HFD and HSD.