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Table 3 Effect of high fat diet feeding on expression of mRNA for methyltransferases

From: High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway

Gene

Control diet

High fat diet

 

mRNA abundance/n factor/10,000

SEM

mRNA abundance/n factor/10,000

SEM

mat1a

6.60

1.10

4.96

0.51

pemt

6.32

0.44

7.27

0.64

gnmt

6.26

1.01

6.81

0.70

  1. Expression of mRNA for mat1a, pemt and gnmt. Rats were fed standard low fat diet (Control diet) or a high fat diet for 18 weeks. The livers were then excised, total mRNA was extracted and the relative abundance of transcripts for mat1a, pemt and gnmt was assessed by qPCR and expressed as mRNA abundance/normalisation factor (n factor)/10,000. Data are the mean from 7 (Control diet) or 10 (High fat diet) animals.
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Lipids in Health and Disease

ISSN: 1476-511X