Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

Ramakrishnan, Lakshmy; Sachdev, Harshpal S; Sharma, Meenakshi; Abraham, Ransi; Prakash, Swami; Gupta, Dileep; Singh, Yogendra; Bhaskar, Seema; Sinha, Shikha; Chandak, Giriraj R; Reddy, Kolli S; Santosh, Bhargava

doi:10.1186/1476-511X-10-68

Lipids in Health and Disease

Table 2 Association of APOA 5 (-1131T > C, S19W), HL (C-514T) and PPAR γ (Pro12Ala) genotypes with lipid variables in adults

From: Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

Genotype (n)	Cholesterol (mg/dl)	Triglycerides (mg/dl)	Total HDL (mg/dl)	HDL2 (mg/dl) ^*	LDL (mg/dl)	LDL particle size (nm)
*APOA5* (-1131T > C)
TT (779)	191.5 ± 41.3	126.9 ± 70.1	47.5 ± 11.4	17.0 (13.0-21.0)	118.4 ± 34.8	27.0 ± 0.6
TC (350)	196.9 ± 41.9	150.5 ± 96.7	46.1 ± 11.7	17.0 (13.0-21.0)	119.6 ± 34.8	26.9 ± 0.6
CC (41)	205.2 ± 43.2	184.4 ± 104.1	46.0 ± 10.5	18.0 (13.5-22.5)	122.3 ± 34.4	27.0 ± 0.6
P value	0.025	<0.0001	0.132	0.822	0.703	0.760
P value (linear trend)	0.007	<0.0001	0.055	0.558	0.418	0.550
Deviation from linearity	0.714	0.505	0.542	0.827	0.823	0.661
P value (Dominant Model) (1129/41)	0.068	<0.0001	0.562	0.619	0.522	0.978
P value (Recessive Model) (779/391)	0.015	<0.0001	0.044	0.624	0.487	0.480
*APOA5* (S19W)
SS (1000)	192.3 ± 41.7	133.2 ± 80.2	46.9 ± 11.5	17.0 (13.0-21.0)	118.5 ± 35.1	27.0 ± 0.6
SW/WW (84)	197.1 ± 41.2	149.9 ± 89.8	45.9 ± 13.1	18.0 (14.0-20.75)	120.7 ± 33.6	26.9 ± 0.7
P value (Dominant Model) (1081/3)	0.324	0.030	0.016	0.928	0.542	0.417
P value (Recessive Model) (1000/84)	0.312	0.069	0.461	0.742	0.578	0.491
HL (C-514T)
CC (756)	191.8 ± 40.0	133.7 ± 80.8	47.1 ± 11.6	17.0 (12.0-20.0)	117.6 ± 33.4	27.0 ± 0.6
CT(434)	194.7 ± 43.4	134.6 ± 78.8	47.6 ± 11.7	18.0 (14.0-23.0)	119.7 ± 36.4	27.0 ± 0.6
TT(76)	196.6 ± 48.6	159.6 ± 100.0	46.3 ± 12.3	18.0 (13.0-23.0)	118.2 ± 38.6	26.9 ± 0.5
P value	0.404	0.029	0.591	0.002	0.604	0.090
P value (linear trend)	0.180	0.065	0.960	0.002	0.460	0.921
Deviation from linearity	0.893	0.056	0.306	0.098	0.496	0.028
P value (Dominant Model) (1190/76)	0.451	0.008	0.450	0.451	0.958	0.106
P value (Recessive Model) (756/510)	0.196	0.318	0.669	<0.0001	0.348	0.367
*PPARγ* (Pro12Ala)
Pro12Pro (916)	193.0 ± 41.6	136.2 ± 82.4	47.1 ± 11.8	17.0 (13.0-21.0)	118.1 ± 34.2	27.0 ± 0.7
Pro12Ala/Ala12Ala (245)	195.4 ± 44.3	138.7 ± 80.7	47.7 ± 11.4	17.0 (14.0-21.75)	119.8 ± 38.7	27.0 ± 0.6
P value (Dominant Model) (1143/18)	0.136	0.029	0.820	0.110	0.415	0.493
P value (Recessive Model) (916/245)	0.437	0.671	0.473	0.173	0.496	0.530

Values are mean ± SD
* Transformed (square root) values were used.

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ISSN: 1476-511X

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