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Table 4 Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance of subjects categorized by sex

From: Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

  Presence of MetS HOMA-IR§ >1.98 Serum HMW adiponectin <2.97 μg/mL
Characteristics AUC (95% CI) P -value AUC (95% CI) P -value AUC (95% CI) P -value
Men, N = 614  
Triglycerides (mg/dL) 0.81 (0.76-0.86) <0.001 0.73 (0.68-0.78) <0.001 0.67 (0.63-0.71) <0.001
HDL cholesterol (mg/dL) 0.28 (0.22-0.34) <0.001 0.31 (0.26-0.36) <0.001 0.40 (0.35-0.44) <0.001
LDL cholesterol (mg/dL) 0.56 (0.50-0.63) <0.001 0.60 (0.54-0.65) <0.001 0.51 (0.47-0.56) 0.577
Non-HDL cholesterol (mg/dL) 0.68 (0.62-0.74) <0.001 0.66 (0.61-0.71) <0.001 0.56 (0.51-0.61) 0.011
Total cholesterol/HDL cholesterol ratio 0.76 (0.70-0.81) <0.001 0.73 (0.68-0.78) <0.001 0.61 (0.56-0.65) <0.001
Triglycerides/HDL cholesterol ratio 0.82 (0.77-0.87) <0.001 0.75 (0.70-0.80) <0.001 0.67 (0.63-0.71) <0.001
LDL-cholesterol/HDL-cholesterol ratio 0.68 (0.62-0.74) <0.001 0.69 (0.63-0.74) <0.001 0.57 (0.53-0.62) 0.002
Women, N = 779       
Triglycerides (mg/dL) 0.83 (0.77-0.89) <0.001 0.68 (0.64-0.73) <0.001 0.63 (0.56-0.70) <0.001
HDL cholesterol (mg/dL) 0.25 (0.19-0.32) <0.001 0.38 (0.29-0.39) <0.001 0.28 (0.22-0.34) <0.001
LDL cholesterol (mg/dL) 0.62 (0.54-0.69) 0.021 0.60 (0.56-0.65) <0.001 0.54 (0.47-0.62) 0.218
Non-HDL cholesterol (mg/dL) 0.70 (0.63-0.78) 0.457 0.64 (0.59-0.69) <0.001 0.59 (0.52-0.66) 0.014
Total cholesterol/HDL cholesterol ratio 0.78 (0.72-0.84) <0.001 0.69 (0.65-0.74) <0.001 0.70 (0.63-0.76) <0.001
Triglycerides/HDL cholesterol ratio 0.84 (0.78-0.89) <0.001 0.70 (0.65-0.74) <0.001 0.69 (0.62-0.75) <0.001
LDL cholesterol/HDL cholesterol ratio 0.74 (0.68-0.81) <0.001 0.68 (0.63-0.72) <0.001 0.68 (0.62-0.75) <0.001
  1. ROC, receiver operating characteristics; MetS, metabolic syndrome; HOMA-IR, homeostasis model assessment of insulin resistance; HMW, high molecular weight; AUC, area under ROC curve; CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein. §HOMA-IR was calculated using the following formula; {fasting blood glucose (mg/dL) X immuno-reactive insulin (mU/mL)}/405. Insulin resistance was defined as values exceeding the fourth quartile of HOMA-IR, and less than the first quartile of serum HMW adiponectin, respectively.