Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

Table 4 Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance of subjects categorized by sex

	Presence of MetS		HOMA-IR§ >1.98		Serum HMW adiponectin <2.97 μg/mL
Characteristics	AUC (95% CI)	P -value	AUC (95% CI)	P -value	AUC (95% CI)	P -value
Men, N = 614
Triglycerides (mg/dL)	0.81 (0.76-0.86)	<0.001	0.73 (0.68-0.78)	<0.001	0.67 (0.63-0.71)	<0.001
HDL cholesterol (mg/dL)	0.28 (0.22-0.34)	<0.001	0.31 (0.26-0.36)	<0.001	0.40 (0.35-0.44)	<0.001
LDL cholesterol (mg/dL)	0.56 (0.50-0.63)	<0.001	0.60 (0.54-0.65)	<0.001	0.51 (0.47-0.56)	0.577
Non-HDL cholesterol (mg/dL)	0.68 (0.62-0.74)	<0.001	0.66 (0.61-0.71)	<0.001	0.56 (0.51-0.61)	0.011
Total cholesterol/HDL cholesterol ratio	0.76 (0.70-0.81)	<0.001	0.73 (0.68-0.78)	<0.001	0.61 (0.56-0.65)	<0.001
Triglycerides/HDL cholesterol ratio	0.82 (0.77-0.87)	<0.001	0.75 (0.70-0.80)	<0.001	0.67 (0.63-0.71)	<0.001
LDL-cholesterol/HDL-cholesterol ratio	0.68 (0.62-0.74)	<0.001	0.69 (0.63-0.74)	<0.001	0.57 (0.53-0.62)	0.002
Women, N = 779
Triglycerides (mg/dL)	0.83 (0.77-0.89)	<0.001	0.68 (0.64-0.73)	<0.001	0.63 (0.56-0.70)	<0.001
HDL cholesterol (mg/dL)	0.25 (0.19-0.32)	<0.001	0.38 (0.29-0.39)	<0.001	0.28 (0.22-0.34)	<0.001
LDL cholesterol (mg/dL)	0.62 (0.54-0.69)	0.021	0.60 (0.56-0.65)	<0.001	0.54 (0.47-0.62)	0.218
Non-HDL cholesterol (mg/dL)	0.70 (0.63-0.78)	0.457	0.64 (0.59-0.69)	<0.001	0.59 (0.52-0.66)	0.014
Total cholesterol/HDL cholesterol ratio	0.78 (0.72-0.84)	<0.001	0.69 (0.65-0.74)	<0.001	0.70 (0.63-0.76)	<0.001
Triglycerides/HDL cholesterol ratio	0.84 (0.78-0.89)	<0.001	0.70 (0.65-0.74)	<0.001	0.69 (0.62-0.75)	<0.001
LDL cholesterol/HDL cholesterol ratio	0.74 (0.68-0.81)	<0.001	0.68 (0.63-0.72)	<0.001	0.68 (0.62-0.75)	<0.001

ROC, receiver operating characteristics; MetS, metabolic syndrome; HOMA-IR, homeostasis model assessment of insulin resistance; HMW, high molecular weight; AUC, area under ROC curve; CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein. §HOMA-IR was calculated using the following formula; {fasting blood glucose (mg/dL) X immuno-reactive insulin (mU/mL)}/405. Insulin resistance was defined as values exceeding the fourth quartile of HOMA-IR, and less than the first quartile of serum HMW adiponectin, respectively.

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