Simvastatin inhibits atherosclerotic lesion formation in apoE-/- mice fed a high-fat diet. A, Representative of Oil Red O-stained aortic sections (10× magnification). B, Quantitation of lesion areas in Oil Red O-stained aortic sections by Image-Pro Plus software. C, Quantification of atherosclerotic lesions in the en-face of the aortic arch. ** P < 0.01 versus model group.