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Figure 1 | Lipids in Health and Disease

Figure 1

From: α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes

Figure 1

Effects of SA on primary rat hepatocytes. (A) Treatment with stearic acid (SA) for 16 h produced significant and concentration-dependent effects on MTT reduction and LDH release. Data represent mean ± S.E.M., n = 5,*P < 0.05 vs. control (0 μmol/l stearic acid), **P < 0.05 vs. stearic acid-only cells. (B) Treatment of primary rat hepatocytes with 250 μmol/L SA produced a significant increase in activity of caspase-3. For comparison, the effects of thapsigargin(Thap; 5 μmol/l)are also shown. Data represent mean ± S.E.M., n = 5,*P < 0.05 vs. control (0 μmol/l stearic acid), **P < 0.05 vs. stearic acid-only cells.

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