Table 3 Selected pathways and genes dominantly regulated in dyslipidemic subjects (FO-D) in response to fish oil supplementation for twelve weeks
| Â | Pathway | Gene name | Gene symbol | Entrez_ID | Ratio t12: t0 |
|---|---|---|---|---|---|
Lipid metabolism | Fatty acid biosynthesis | acetyl-CoA carboxylase beta | ACACB | 32 | -4.67 |
| Â | Fatty acid elongation in mitochondria | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | HADHA | 3030 | -3.70 |
| Â | Â | hydroxyacyl-CoA dehydrogenase | HADH | 3033 | -2.34 |
| Â | Fatty acid metabolism | enoyl-CoA delta isomerase 2 | ECI2 | 10455 | -4.54 |
| Â | Â | enoyl-CoA delta isomerase 1 | ECI1 | 1632 | 6.02 |
| Â | Â | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | HADHA | 3030 | -3.70 |
| Â | Â | hydroxyacyl-CoA dehydrogenase | HADH | 3033 | -2.34 |
| Â | Â | acyl-CoA dehydrogenase, short/branched chain | ACADSB | 36 | -13.69 |
| Â | Â | aldehyde dehydrogenase 2 family (mitochondrial) | ALDH2 | 217 | 3.26 |
| Â | Glycerolipid metabolism | 1-acylglycerol-3-phosphate O-acyltransferase 6 | AGPAT6 | 137964 | 2.67 |
|  |  | diacylglycerol kinase, alpha 80 kDa | DGKA | 1606 | 2.47 |
| Â | Â | diacylglycerol kinase, eta | DGKH | 160851 | -3.05 |
|  |  | diacylglycerol kinase, theta 110 kDa | DGKQ | 1609 | 3.40 |
| Â | Â | aldehyde dehydrogenase 2 family (mitochondrial) | ALDH2 | 217 | 3.26 |
| Â | Â | monoacylglycerol O-acyltransferase 3 | MOGAT3 | 346606 | -3.48 |
| Â | Glycerophospholipid metabolism | 1-acylglycerol-3-phosphate O-acyltransferase 6 | AGPAT6 | 137964 | 2.67 |
| Â | Â | phospholipase B1 | PLB1 | 151056 | 11.68 |
|  |  | diacylglycerol kinase, alpha 80 kDa | DGKA | 1606 | 2.47 |
| Â | Â | diacylglycerol kinase, eta | DGKH | 160851 | -3.05 |
|  |  | diacylglycerol kinase, theta 110 kDa | DGKQ | 1609 | 3.40 |
| Â | Â | phospholipase A2, group IIE | PLA2G2E | 30814 | 2.51 |
| Â | Â | phosphatidylserine synthase 1 | PTDSS1 | 9791 | -2.84 |
| Â | Arachidonic acid metabolism | phospholipase B1 | PLB1 | 151056 | 11.68 |
| Â | Â | gamma-glutamyltransferase 5 | GGT5 | 2687 | 7.98 |
| Â | Â | glutathione peroxidase 3 (plasma) | GPX3 | 2878 | -2.15 |
| Â | Â | glutathione peroxidase 5 | GPX5 | 2880 | -2.41 |
| Â | Â | phospholipase A2, group IIE | PLA2G2E | 30814 | 2.51 |
| Â | Linoleic acid metabolism | phospholipase B1 | PLB1 | 151056 | 11.68 |
| Â | Â | phospholipase A2, group IIE | PLA2G2E | 30814 | 2.51 |
| Â | Alpha-linolenic acid metabolism | phospholipase B1 | PLB1 | 151056 | 11.68 |
| Â | Â | phospholipase A2, group IIE | PLA2G2E | 30814 | 2.51 |
Immune system | Complement and coagulation cascades | complement component (3b/4b) receptor 1 | CR1 | 1378 | -3.37 |
| Â | Â | coagulation factor III (thromboplastin, tissue factor) | F3 | 2152 | -4.23 |
| Â | Â | fibrinogen gamma chain | FGG | 2266 | -12.30 |
| Â | Â | serpin peptidase inhibitor, clade C (antithrombin), member 1 | SERPINC1 | 462 | 3.23 |
Cardiovascular diseases | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | desmocollin 2 | DSC2 | 1824 | -2.50 |
| Â | Â | calcium channel, voltage-dependent, gamma subunit 5 | CACNG5 | 27091 | -9.92 |
| Â | Â | integrin, alpha 3 | ITGA3 | 3675 | -4.32 |
| Â | Â | transcription factor 7-like 1 | TCF7L1 | 83439 | -4.93 |
| Â | Dilated cardiomyopathy | adenylate cyclase 7 | ADCY7 | 113 | -2.13 |
| Â | Â | calcium channel, voltage-dependent, gamma subunit 5 | CACNG5 | 27091 | -9.92 |
| Â | Â | integrin, alpha 3 | ITGA3 | 3675 | -4.32 |
| Â | Â | myosin, light chain 2, regulatory, cardiac, slow | MYL2 | 4633 | 2.68 |