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Table 4 Effect of diets on plasma lipid profiles and hepatic lipid contents in rats fed hypercholesterolemic diets and treated with doses of β-conglycinin, fenofibrate, rosuvastatin and mixtures.

From: β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats

  Dietary groups
  HC HC+7S HC+FF HC+RO HC+7S+FF HC+7S+RO
Plasma (mmol/L)       
Total cholesterol 3.88 ± 0.22 2.99 ± 0.10* 2.49 ± 0.15** 3.15 ± 0.12* 2.33 ± 0.22** 4.00 ± 0.12
HDL-C 0.45 ± 0.02 0.70 ± 0.05* 0.88 ± 0.13* 0.68 ± 0.06 0.93 ± 0.10** 0.90 ± 0.15*
non-HDL-C 3.43 ± 0.12 2.29 ± 0.10** 1.61 ± 0.06** 2.47 ± 0.14** 1.39 ± 0.12** 2.91 ± 0.22*
Triacylglycerides 0.92 ± 0.05 0.60 ± 0.04** 0.50 ± 0.02** 0.85 ± 0.07 0.49 ± 0.03** 0.70 ± 0.05*
AI* 8.09 ± 0.07 3.52 ± 0.11** 1.96 ± 0.12** 4.09 ± 0.35** 1.53 ± 0.15** 3.67 ± 0.33**
Liver (μmol/g)       
Total cholesterol 58.43 ± 0.85 46.22 ± 0.65** 39.58 ± 0.85** 36.04 ± 2.07** 37.86 ± 0.80** 47.13 ± 2.12**
Triacylglycerides 56.97 ± 2.15 48.52 ± 2.28* 60.06 ± 1.76 41.42 ± 2.46** 47.64 ± 2.38* 46.05 ± 2.59*
  1. 1Values are means ± SEM for nine rats. *p < 0.05 and **p < 0.001 by the Bonferroni t-test multiple comparisons versus control group (HC). HC = hypercholesterolemic diet; HC+7S = HC diet + β-conglycinin 300 mg/kg/day; HC+FF = HC diet + fenofibrate 30 mg/kg/day; HC+RO = HC diet + rosuvastatin 10 mg/kg/day; HC+7S+FF = HC diet + β-conglycinin + fenofibrate, 300 and 30 mg/kg/day respectively, and HC+7S+RO = HC diet + β-conglycinin + rosuvastatin, 300 and 10 mg/kg/day respectively. * AI = atherogenic index ware calculated as proposed by Liu et al. (2006).