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Figure 1 | Lipids in Health and Disease

Figure 1

From: Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases

Figure 1

Man-Lam and PGL-1 inhibit TCR- and TCR/CD28-induced Zap70 phosphorylation. Untreated or antigen-pretreated Jurkat T-cells were stimulated with α-CD3 or α-CD3 + α-CD28 antibodies, and immunoblots were performed as described in Material and Methods. Membranes were stripped and reprobed with anti-β-actin antibody to confirm equal loading. Histograms represent mean ± SEM values of normalised band intensities of 3 experiments.

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