Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity

Table 2 Effects of dietary supplementation of AqFSC, EtFSC, or fenofibrate on body weight gain and food/drug intake in the normal and hypercholesterolemic mice

Groups	Body weight gain (g)	Body-liver weight (g)	Food intake (g/mouse/day)	Drug intake (g/kg/day)
*Normal diet for 13 days*
Normal diet	8.55 ± 0.11	24.64 ± 0.36	4.20
1% AqFSC/normal diet	8.11 ± 0.19	24.63 ± 0.63	4.55	1.45
4% AqFSC/normal diet	8.05 ± 0.34	24.15 ± 0.58	4.32	5.56
1% EtFSC/normal diet	8.31 ± 0.15	24.53 ± 0.43	4.43	1.35
4% EtFSC/normal diet	8.45 ± 0.25	24.38 ± 0.43	4.21	5.43
0.1% Fenofibrate/normal diet	5.09 ± 0.08*	20.40 ± 0.28*	4.53	0.18
*HFCB diet for 13 days*
Normal diet	8.00 ± 0.43	25.72 ± 0.63	4.31	-
HFCB diet	7.52 ± 0.25	24.96 ± 0.54	3.85	-
1% AqFSC/HFCB diet	8.23 ± 0.67	24.76 ± 0.59	4.56	1.59
4% AqFSC/HFCB diet	7.96 ± 0.42	25.49 ± 0.63	4.89	6.68
1% EtFSC/HFCB diet	8.80 ± 0.35	25.29 ± 0.76	5.50	1.99
4% EtFSC/HFCB diet	8.71 ± 0.52	25.25 ± 0.72	4.23	6.13
0.1% Fenofibrate/HFCB diet	7.33 ± 0.32	22.51 ± 0.72^†	4.31	0.17

Experimental details were described in Table1. The dosages (g/kg/day) based on crude herbal material were determined with respect to the amount of ingested diet (g/day/kg) and drug concentrations in the diet. Values given are the mean ± S.E.M., with n = 10. *Significantly different from the normal diet group (p < 0.01); ^†significantly different from the hypercholesterolemic mice (p < 0.01).

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