Interaction of genes involved in lysophospholipid metabolism. The novel finding is that skeletal muscle tissue expresses the genes regulating these pathways. The enzymes are in boxes and each is known to catalyze the reaction in the figure. The new data demonstrates that skeletal muscle tissue expresses a key LPA receptor (EDG2), and expresses a Rho kinase (ROCK2) well-known to be activated by LPA. In addition to platelet aggregation, ROCK2 has been associated with inflammation. The red pathway indicates a pathway to inflammation and the blue pathways would lead to an attenuation of LPA effects. Of these genes, only LPP1 is affected by physical inactivity. Abbreviations: LPC, lysophosphatidylcholine; LPA, lysophosphatidic acid; AGPAT, 1-acylglycerol-3-phosphate acyltransferase; EDG2, endothelial differentiation gene 2; LPP, lipid phosphate phosphatase; LYPLA, lysophospholipase; ROCK2, Rho-associated, coiled-coil containing protein kinase 2.