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Figure 1 | Lipids in Health and Disease

Figure 1

From: Dual functions of Insig proteins in cholesterol homeostasis

Figure 1

Feedback control of cholesterol synthesis through binding to Insigs. HMG-CoA reductase is subject to feedback inhibition by cholesterol, oxysterols and lanosterol. Cholesterol binding to SCAP causes a conformational change that induces SCAP to bind to Insigs. So, cholesterol inhibits reductase activity by suppressing the activation of SREBPs. Oxysterols binding to Insigs inhibit reductase by accelerating its degradation and by suppressing the activation of SREBPs. Lanosterol down-regulates reductase solely by accelerating degradation of the enzyme.

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Lipids in Health and Disease

ISSN: 1476-511X