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Table 3 Subject fatty acid profiles.

From: Subcutaneous adipose tissue fatty acid desaturation in adults with and without rare adipose disorders

 

Group

 

Control (n = 6)

DD (n = 6)

FML (n = 8)

MSL (n = 5)

 

Saturated and Monounsaturated Fatty Acids Percent of Total (SEM)

14:0 (myristic)

1.22 (1.17-1.38)

1.74 (1.52-1.78)**†

1.30 (1.08-1.47)

1.53 (1.12-2.29)

16:0 (palmitic)

27.4 (24.8-28.5)

27.3 (26.0-29.2)

25.4 (25.2-28.3)

26.3 (23.0-31.6)

16:1n-7 (palmitoleic)

3.68 (2.90-4.04)

2.78 (2.18-3.43)

2.71 (2.27-3.28)

4.04 (3.24-4.95)

18:0 (stearic)

4.15 (3.93-5.52)

6.07 (5.81-7.92)

5.80 (5.59-7.21)

3.88 (2.21-7.72)

18:1X ¥

1.95 (1.87-2.54)

1.52 (1.12-1.92)

1.91 (1.43-2.01)

1.71 (1.27-2.14)

18:1n-9 (oleic)

47.8 (46.1-48.9)

48.5 (47.5-49.0)

48.2 (46.9-48.7)

46.6 (43.3-51.9)

18:1n-7 (vaccenic)

3.22 (2.72-5.70)

2.01 (1.72-2.61)†‡

5.85 (4.09-6.25)

2.95 (2.64-6.31)

18:1Y ¥

0.82 (0.75-0.94)

not detected

2.22 (2.05-2.38)

0.82 (N/A)

20:1n-9

(eicosenoic) ¥

0.65 (0.60-0.73)

0.60 (0.52-0.72)

0.70 (0.62-0.79)

0.50 (0.49-0.54)

Total percent SFA

33.4 (29.1-34.8)

36.2 (35.7-38.6)

33.0 (31.1-35.5)

31.3 (26.6-41.7)

Total percent MUFA

57.9 (54.8-59.8)

54.4 (53.5-56.2)

57.0 (55.2-60.2)

56.4 (53.1-61.0)

 

Polyunsaturated Fatty Acids Percent of Total (SEM)

18:2n-6

(linoleic, LA)

9.12 (8.31-10.4)

8.34 (8.10-8.89)

9.65 (8.07-9.94)

5.64 (4.61-8.50)‡

18:3n-3

(α-linolenic, ALA)

0.23 (0.17-0.26)

0.24 (0.18-0.32)

0.21 (0.17-0.26)

0.15 (0.12-0.17)‡†

20:4n-6 (arachidonic, AA)

0.13 (0.10-0.16)

0.10 (0.09-0.13)

0.13 (0.11-0.20)

0.14 (0.13-0.41)#

Total percent PUFA (LA+ALA+AA)

9.49 (8.58-10.8)

8.61 (8.31-9.29)

10.0 (8.35-10.3)

6.21 (5.07-8.80)*

n-6/n-3 ratio (LA+AA)/ALA

(arbitrary units)

43.3 (40.1-50.4)

36.8 (29.2-47.1)

44.6 (37.7-51.4)

40.1(30.5-50.3)

  1. The median percent of total is presented with the 25-75% interquartile range in parentheses. In DD, myristic acid percent of total is increased compared to Controls and FML. Vaccenic acid percent of total trends toward a decrease compared to Controls, but is significantly lower compared to FML
  2. DD Dercum's disease, FML Familial multiple lipomatosis, MSL Multiple symmetric lipomatosis
  3. *p < 0.05 vs. Control; **p < 0.01 vs. Control; †p < 0.05 vs. FML; ‡ trended lower vs. Control (see text);
  4. #trended higher vs.DD; ¥no comparison between groups made due to low prevalence in the groups; N/A non-applicable because not detected in enough subjects to provide a value
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Lipids in Health and Disease

ISSN: 1476-511X