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Figure 3 | Lipids in Health and Disease

Figure 3

From: Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFκB and ERK signaling

Figure 3

Up-regulation of CXCL12-mediated PI3K/AKT, IκBα and ERK signaling in lymphocytes after treatment with WEV or WEV+NP. The phosphorylation of AKT, IκBα, ERK and p38MAPK, which are the main signaling pathways downstream of CXCL12, was monitored in lymphocytes isolated from the three groups of mice using western blot analysis. (A) Protein bands from one representative experiment of the ten performed are shown for pAKT, pIκBα, pERK, p38MAPK and β-actin. (B) The phosphorylation of AKT, IκBα, ERK and p38MAPK was normalized to the total β-actin levels. The results are expressed as the mean ± SEM of normalized phosphorylation values in control (gray bars), WEV-treated (closed black bars) and WEV+NP-treated mice (hatched bars). *P < 0.05, WEV-treated vs. control; #P < 0.05, WEV+NP-treated vs. control; +P < 0.05, WEV+NP-treated vs. WEV-treated groups.

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Lipids in Health and Disease

ISSN: 1476-511X