Skip to main content

Advertisement

Table 8 Histopathological scoring of glomerular damage, acute tubular necrosis, tubulointerstitial nephritis as well as degree of nephrotoxicity after rutin (RT) and/or ascorbic acid (AA) treatments in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation

From: Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats

Treatment (in rat chow) Glomerular damage Acute tubular necrosis Tubulointerstitial nephritis Total score Nephrotoxicity degree
  Male Female Male Female Male Female Male Female Male Female
Control 1 0 0 1 0 1 1 1 No No
HCD (1% cholesterol + 0.5% cholic acid) 2 2 3 2 1 2 6 6 Moderate Moderate
RT (0.2%) + HCD 1 1 1 1 0 0 2 2 Mild Mild
AA (0.4%) + HCD 2 1 1 0 0 1 3 2 Mild Mild
RT (0.1%) + AA (0.2%) + HCD 0 1 0 1 0 0 0 2 No Mild