Table 8 Histopathological scoring of glomerular damage, acute tubular necrosis, tubulointerstitial nephritis as well as degree of nephrotoxicity after rutin (RT) and/or ascorbic acid (AA) treatments in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation
Treatment (in rat chow) | Glomerular damage | Acute tubular necrosis | Tubulointerstitial nephritis | Total score | Nephrotoxicity degree | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Male | Female | Male | Female | Male | Female | Male | Female | Male | Female |
Control | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | No | No |
HCD (1% cholesterol + 0.5% cholic acid) | 2 | 2 | 3 | 2 | 1 | 2 | 6 | 6 | Moderate | Moderate |
RT (0.2%) + HCD | 1 | 1 | 1 | 1 | 0 | 0 | 2 | 2 | Mild | Mild |
AA (0.4%) + HCD | 2 | 1 | 1 | 0 | 0 | 1 | 3 | 2 | Mild | Mild |
RT (0.1%) + AA (0.2%) + HCD | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | No | Mild |