Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels

Wu, Dong-Feng; Yin, Rui-Xing; Hu, Xi-Jiang; Aung, Lynn Htet Htet; Cao, Xiao-Li; Miao, Lin; Li, Qing; Yan, Ting-Ting; Wu, Jin-Zhen; Pan, Shang-Ling

doi:10.1186/1476-511X-11-50

Lipids in Health and Disease

Table 5 Correlative factors for serum lipid parameters

From: Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels

Lipid parameter	Relative factor	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
Both Yao and Han
TC	Age	0.011	0.002	0.181	6.402	0.000
	Body mass index	0.059	0.009	0.180	6.419	0.000
	Ethnic group	0.343	0.054	0.177	6.368	0.000
	Diastolic blood pressure	0.010	0.003	0.115	3.850	0.000
	Alcohol consumption	0.089	0.039	0.064	2.285	0.022
TG	Body mass index	0.078	0.010	0.211	7.567	0.000
	Sex	−0.257	0.071	−0.117	−3.631	0.000
	Alcohol consumption	0.207	0.052	0.133	3.981	0.000
	Ethnic group	0.167	0.063	0.076	2.657	0.008
HDL-C	Age	0.005	0.001	0.174	6.163	0.000
	Alcohol consumption	0.172	0.021	0.275	8.177	0.000
	Sex	0.155	0.029	0.176	5.435	0.000
	Ethnic group	0.115	0.025	0.130	4.548	0.000
	Body mass index	−0.018	0.004	−0.119	−4.252	0.000
	Genotype	−0.049	0.020	−0.066	−2.389	0.017
LDL-C	Body mass index	0.051	0.008	0.193	6.678	0.000
	Age	0.008	0.001	0.167	5.731	0.000
	Ethnic group	0.103	0.045	0.066	2.313	0.021
	Diastolic blood pressure	0.007	0.002	0.089	2.894	0.004
	Alcohol consumption	−0.065	0.032	−0.059	−2.029	0.043
ApoAI	Alcohol consumption	0.156	0.015	0.346	10.638	0.000
	Age	0.004	0.001	0.194	7.111	0.000
	Ethnic group	0.086	0.018	0.136	4.852	0.000
	Genotype	−0.132	0.039	−0.092	−3.420	0.001
	Sex	0.065	0.020	0.103	3.285	0.001
ApoB	Body mass index	0.018	0.002	0.249	8.686	0.000
	Age	0.002	0.000	0.148	5.150	0.000
	Ethnic group	−0.038	0.012	−0.089	−3.237	0.001
	Diastolic blood pressure	0.002	0.001	0.080	2.669	0.008
ApoAI/ApoB	Alcohol consumption	0.267	0.031	0.286	8.523	0.000
	Body mass index	−0.042	0.006	−0.190	−6.777	0.000
	Ethnic group	0.142	0.038	0.108	3.755	0.000
	Sex	0.105	0.043	0.080	2.458	0.014
Bai Ku Yao
TC	Body mass index	0.067	0.016	0.172	4.214	0.000
	Age	0.007	0.002	0.109	2.655	0.008
	Diastolic blood pressure	0.008	0.004	0.083	1.972	0.049
TG	Alcohol consumption	0.258	0.067	0.198	3.872	0.000
	Body mass index	0.054	0.016	0.132	3.302	0.001
	Sex	−0.330	0.106	−0.169	−3.116	0.002
	Cigarette smoking	−0.153	0.070	−0.120	−2.185	0.029
HDL-C	Alcohol consumption	0.126	0.022	0.228	5.777	0.000
	Age	0.004	0.001	0.142	3.586	0.000
	Genotype	−0.245	0.090	−0.106	−2.714	0.007
LDL-C	Body mass index	0.062	0.013	0.194	4.855	0.000
	Age	0.005	0.002	0.098	2.437	0.015
ApoAI	Alcohol consumption	0.143	0.016	0.333	8.708	0.000
	Age	0.003	0.001	0.140	3.655	0.000
	Genotype	−0.177	0.068	−0.099	−2.611	0.009
ApoB	Body mass index	0.019	0.004	0.205	5.064	0.000
	Age	0.002	0.001	0.104	2.564	0.011
	Alcohol consumption	−0.032	0.012	−0.107	−2.611	0.009
	Diastolic blood pressure	0.002	0.001	0.097	2.306	0.021
ApoAI/ApoB	Alcohol consumption	0.311	0.039	0.309	7.940	0.000
	Body mass index	−0.044	0.012	−0.137	−3.522	0.000
Han Chinese
TC	Age	0.016	0.002	0.260	6.443	0.000
	Body mass index	0.050	0.011	0.174	4.374	0.000
	Diastolic blood pressure	0.012	0.004	0.142	3.341	0.001
	Alcohol consumption	0.164	0.061	0.101	2.697	0.007
TG	Body mass index	0.094	0.013	0.270	6.949	0.000
	Cigarette smoking	0.357	0.063	0.221	5.697	0.000
HDL-C	Age	0.006	0.001	0.219	5.533	0.000
	Sex	0.244	0.040	0.264	6.074	0.000
	Alcohol consumption	0.190	0.033	0.250	5.702	0.000
	Body mass index	−0.022	0.005	−0.163	−4.119	0.000
	Genotype	−0.075	0.028	−0.101	−2.635	0.009
LDL-C	Age	0.012	0.002	0.245	5.873	0.000
	Body mass index	0.043	0.009	0.186	4.533	0.000
	Diastolic blood pressure	0.006	0.003	0.090	2.062	0.040
ApoAI	Age	0.005	0.001	0.251	6.600	0.000
	Alcohol consumption	0.165	0.022	0.326	7.621	0.000
	Sex	0.134	0.026	0.217	5.096	0.000
	Genotype	−0.037	0.019	−0.074	−1.979	0.048
ApoB	Body mass index	0.018	0.002	0.323	8.524	0.000
	Age	0.003	0.000	0.228	5.967	0.000
	Cigarette smoking	0.028	0.010	0.105	2.807	0.005
ApoAI/ApoB	Body mass index	−0.039	0.006	−0.256	−6.450	0.000
	Sex	0.232	0.047	0.218	4.931	0.000
	Alcohol consumption	0.184	0.039	0.211	4.724	0.000

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B.

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ISSN: 1476-511X

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