Imbalance in superoxide dismutase/thioredoxin reductase activities in hypercholesterolemic subjects: relationship with low density lipoprotein oxidation

Table 2 Oxidative stress and inflammatory markers in patients with different LDL levels

	Groups (LDL-cholesterol levels)
	Low-LDL	Intermediate-LDL	High-LDL
	(<100 mg/dL)	(100–160 mg/dL)	(>160 mg/dL)
TBARS (nmol MDA/mL)	4.9+ 0.3^b	5.1+ 0.2^b	6.3+ 0.3^a
	(2.5-8.5)	(2.4-8.0)	(4.0-13.3)
Protein carbonyl content	1.2+ 0.1^b	1.4+ 0.1^a	1.9+ 0.2^a
(nmol/mg of protein)	(0.2-2.9)	(0.7-4.9)	(0.5-6.7)
LDLox (mg/L)	0.27+ 0.06^b	0.39+ 0.04^b	0.73+ 0.06^a
	(0.0-1.0)	(0.0-1.7)	(0.03-1.9)
LDLoxAB (mg/L)	10.3+ 2.1^c	22.4+ 1.5^b	32.1+ 1.4^a
	(0.7-36.0)	(0.8-46.4)	(9.2-54.7)
hs-CRP (mg/L)	0.42+ 0.07^b	0.81+ 0.16^b	1.55+ 0.26^a
	(0.1-1.2)	(0.1-7.9)	(0.1-7.9)

Results are expressed as mean + SEM (minimum – maximum). N = 23–50, as shown in Table 1. ^a,b,c Values within the same line that do not share a common superscript letter are significantly different from each other (p < 0.05). TBARS = thiobarbituric acid reactive substances; MDA = malondialdehyde; LDLox = oxidized LDL; LDLoxAB = LDLox autoantibodies; hs-CRP = highly sensitive C-reactive protein.

ISSN: 1476-511X