Functional changes in adipose tissue in a randomised controlled trial of physical activity

Sjögren, Per; Sierra-Johnson, Justo; Kallings, Lena V; Cederholm, Tommy; Kolak, Maria; Halldin, Mats; Brismar, Kerstin; de Faire, Ulf; Hellénius, Mai-Lis; Fisher, Rachel M

doi:10.1186/1476-511X-11-80

Lipids in Health and Disease

Table 1 Baseline characteristics and follow-up changes of selected variables

From: Functional changes in adipose tissue in a randomised controlled trial of physical activity

	Baseline^a		Change^b		Between group diff
	Control n = 43	Intervention n = 30	Control	Intervention	P^ANCOVA
Age (yr)	67.5 (0.5)	67.6 (0.5)	-	-
Female (%)	58	63	-	-
Exercise time (min/w)	120 (5, 205)	135 (40, 215)	0 (-105, 240)	+137 (0, 490)^**	0.03
Steps per day	5200 (2730)	5900 (2800)	+719 (2490)	+1190 (3270)	0.28
Dietary improvements (%)^c	-	-	12	49	0.001
Weight (kg)	89 (81, 95)	82 (73, 97)	-0.1 (-1.1, 0.9)	-1.8 (-3.9, 0.3)^**	0.02
BMI (kg/m²)	30.3 (28.6, 31.8)^††	27.5 (26.6, 30.8)	-0.04 (-0.47, 0.30)	-0.68 (-1.21, 0.11)^**	0.04
Waist circumference (cm)	107 (8)^†	103 (10)	-1.3 (3.1)^**	-2.6 (4.0)^**	0.12
Body fat mass (kg)	31.4 (28.1, 38.7)^†	29.8 (24.7, 31.6)	-0.5 (-1.9, 0.4)^*	-1.5 (-3.6, -0.4)^**	0.04
Systolic blood pressure (mmHg)	144 (17)	136 (16)	-5 (11)^*	-0 (15)	0.61
Diastolic blood pressure (mmHg)	81 (9)	78 (10)	-1 (8)	-1 (9)	0.61
Insulin (uU/mL)	10.9 (6.8, 14.1)^†	8.2 (6.4, 10.9)	-0.85 (-2.98, 0.89)	-0.90 (-2.97, 0.46)^*	0.16
Glucose (mmol/L)	5.4 (4.9, 5.7)	5.3 (4.9, 5.5)	-0.2 (-0.4, 0.1)^**	-0.1 (-0.3, 0.1)	0.79
HOMA	2.6 (1.7, 3.6)^†	1.9 (1.7, 2.3)	-0.2 (-0.9, 0.3)	-0.2 (-0.7, 0.1)	0.19
HbA1c (%)	4.8 (4.6, 5.0)	4.9 (4.7, 5.2)	0.1 (0.0, 0.3)^**	-0.1 (-0.2, 0.1)	0.0003
Triacylglycerol (mmol/L)	1.2 (1.0, 1.6)	1.1 (1.0, 1.5)	-0.0 (-0.3, 0.2)	-0.1 (-0.3, 0.1)^*	0.23
Cholesterol (mmol/L)	5.6 (0.9)	5.9 (1.0)	0.0 (0.6)	-0.3 (1.0)	0.14
HDL (mmol/L)	1.7 (1.4, 1.9)	1.7 (1.5, 1.9)	-0.1 (-0.1, 0.1)	+0.0 (-0.2, 0.2)	0.57
ApoB/A1	0.73 (0.14)	0.78 (0.20)	-0.04 (0.11)^*	-0.08 (0.15)^**	0.27
C-reactive protein (mg/L)	1.9 (1.1, 4.0)	1.7 (0.8, 3.4)	+0.2 (-0.4, 1.5)	+0.1 (-0.7, 0.6)	0.20
Adiponectin (mg/L)	16 (10, 21)	20 (14, 24)	-0.1 (-1.5, 1.3)	+0.3 (-1.0, 1.3)	0.21
Leptin (ng/mL)	22 (13, 36)	15 (13, 23)	-1.1 (-5.0, 0.5)	-1.8 (-8.8, 0.3) ^**	0.011

Values are mean (SD) or median (IQR) and changes denote measure_(follow-up) – measure_(baseline).
Total number of individuals analysed varies slightly due to technical reasons.
^a Significant differences between groups at baseline: †P < 0.05, ††P < 0.01.
^b Significant within-group changes: *P < 0.05,**P < 0.01.
^c Defined as changes (according to self-reported frequencies) in the consumption of at least three of the following dietary variables: vegetables, fruit, seafood, candy, buns, snacks, high fat cheese, pizza and soda.
HOMA, homeostasis model assessment of insulin resistance; HDL, high density lipoprotein; ApoB/A1, ratio between apolipoproteins B and A1.

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ISSN: 1476-511X

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