Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

Table 1 Clinical characteristics of study subjects by Mt5178 C/A genotype

	Mt5178C	Mt5178A	P value
	N = 239	N = 155	P value
Age (y)	54.3 ± 7.8	53.2 ± 7.8	0.171
Body Mass Index (kg/m²)	23.3 ± 2.8	23.5 ± 2.6	0.461
Serum total cholesterol (mg/dl)	203.5 ± 34.3	202.1 ± 31.8	0.672
Serum HDL cholesterol (mg/dl)	54.6 ± 13.6	56.3 ± 16.2	0.269
Serum LDL cholesterol (mg/dl)	121.6 ± 34.8	117.9 ± 30.5	0.281
Serum Triglyceride (mg/dl)	136.7 ± 91.1	139.5 ± 90.8	0.766
Systolic blood pressure (mmHg)	125.8 ± 15.9	125.7 ± 14.1	0.940
Diastolic blood pressure (mmHg)	74.0 ± 10.7	73.8 ± 9.1	0.823
Fasting plasma glucose (mg/dl)	97.2 ± 9.4	97.6 ± 9.7	0.672
Smoking status (never- or ex-/ 1–20 cigarettes per day/ >20 cigarettes per day) (%)	59.4/29.7/10.9	59.4/25.8/14.8	0.429
Alcohol consumption (daily/occasionally/non- or ex-) (%)	46.4/35.2/18.4	47.7/38.7/13.6	0.426
Coffee consumption (≤ 1 cup per day/2-3 cups per day/≥ 4 cups per day) (%)	61.1/29.7/9.2	55.5/32.9/11.6	0.510
Antihypertensive medication use (%)	18.8	12.9	0.122
Hypo-HDL cholesterolemia (%)	11.7	12.3	0.871
Hyper-LDL cholesterolemia (%)	26.4	25.8	0.903
Hypertriglyceridemia (%)	29.7	29.7	0.995

HDL; high-density lipoprotein. LDL; low-density lipoprotein. Age, body mass index, serum HDL cholesterol levels, serum LDL cholesterol levels, serum triglyceride levels, systolic blood pressure, diastolic blood pressure, fasting plasma glucose levels are given as means ± S.D. For smoking status, coffee consumption, alcohol consumption, antihypertensive medication use, hypo-HDL cholesterolemia, hyper-LDL cholesterolemia and hypertriglyceridemia, P values were calculated by chi-squared test. All P values depict significance of differences between Mt5178C and Mt5178A.

ISSN: 1476-511X