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Table 2 Effects of α, β-amyrin and fenofibrate treatments on serum lipid parameters in mice

From: Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Lipid parameter Normal diet (control) High-fat diet and treated
   Vehicle Control α, β-amyrin 10 mg/kg α, β-amyrin 30 mg/kg α, β-amyrin 100 mg/kg Fenofibrate 200 mg/kg
Total cholesterol (mg/dL) 119.00 ± 5.86 225.40 ± 10.92a 175.90 ± 9.62b 175.60 ± 13.32b 166.30 ± 8.97b 143.40 ± 7.48b
Triglycerides (mg/dL) 48.85 ± 5.94 258.80 ± 27.48a 204.7 ± 26.01b 146.70 ± 21.24b 50.50 ± 6.66b 70.71 ± 13.48b
HDL-c (mg/dL) 26.13 ± 1.42 39.00 ± 1.59a 48.63 ± 4.78 63.38 ± 7.12b 71.25 ± 3.21b 71.14 ± 3.92b
VLDL-c (mg/dL) 9.75 ± 1.18 48.91 ± 5.45a 40.94 ± 5.20 33.65 ± 4.21b 10.10 ± 1.33b 14.14 ± 2.69b
LDL-c (mg/dL) 83.29 ± 7.07 137.20 ± 12.32a 81.38 ± 16.00b 100.10 ± 12.88b 90.65 ± 11.22b 58.14 ± 8.62b
Atherogenic index (AI) 3.65 ± 0.32 4.78 ± 0.34a 3.01 ± 0.45b 2.23 ± 0.49b 1.46 ± 0.22b 1.09 ± 0.21b
  1. Each value represents the mean ± S.E.M. (n = 8). a p < 0.05 compared with normal diet-fed control. b p < 0.05 compared with vehicle control.