Lipids in Health and Disease

Table 2 Effects of α, β-amyrin and fenofibrate treatments on serum lipid parameters in mice

From: Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Lipid parameter	Normal diet (control)	High-fat diet and treated
		Vehicle Control	α, β-amyrin 10 mg/kg	α, β-amyrin 30 mg/kg	α, β-amyrin 100 mg/kg	Fenofibrate 200 mg/kg
Total cholesterol (mg/dL)	119.00 ± 5.86	225.40 ± 10.92^a	175.90 ± 9.62^b	175.60 ± 13.32^b	166.30 ± 8.97^b	143.40 ± 7.48^b
Triglycerides (mg/dL)	48.85 ± 5.94	258.80 ± 27.48^a	204.7 ± 26.01^b	146.70 ± 21.24^b	50.50 ± 6.66^b	70.71 ± 13.48^b
HDL-c (mg/dL)	26.13 ± 1.42	39.00 ± 1.59^a	48.63 ± 4.78	63.38 ± 7.12^b	71.25 ± 3.21^b	71.14 ± 3.92^b
VLDL-c (mg/dL)	9.75 ± 1.18	48.91 ± 5.45^a	40.94 ± 5.20	33.65 ± 4.21^b	10.10 ± 1.33^b	14.14 ± 2.69^b
LDL-c (mg/dL)	83.29 ± 7.07	137.20 ± 12.32^a	81.38 ± 16.00^b	100.10 ± 12.88^b	90.65 ± 11.22^b	58.14 ± 8.62^b
Atherogenic index (AI)	3.65 ± 0.32	4.78 ± 0.34^a	3.01 ± 0.45^b	2.23 ± 0.49^b	1.46 ± 0.22^b	1.09 ± 0.21^b

Each value represents the mean ± S.E.M. (n = 8). ^a p < 0.05 compared with normal diet-fed control. ^b p < 0.05 compared with vehicle control.

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