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Figure 4 | Lipids in Health and Disease

Figure 4

From: Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9

Figure 4

Effect of PCSK9 on HDL cholesterol concentration in mice having a wild-type control, Ldlr KO or Apoe KO background. Fasting plasma samples were obtained from 3-month-old mice (n = 5 per genotype) fed a normal chow diet. HDL cholesterol concentrations were measured in mice that expressed normal endogenous PCSK9 (white control bars) or were deficient in PCSK9 (black bars). Data represent the mean ± SEM. P < 0.0001.

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