Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults

Table 3 The fasting serum lipid levels in mmol/L (mean and standard error) according to the APOE, SCARB1, PPARα genotypes

The genotypes	TC	LDL-C	HDL-C	LnTG
The genotypes	Mean (SE)	Mean (SE)	Mean (SE)	Mean (SE)
		MEN
*APOE*
APOE3	5.38 (0.06)	3.49 (0.06)	1.30 (0.03)	0.35 (0.02)
APOE2	5.03 (0.12)*	3.00 (0.11)*	1.24 (0.05)	0.47 (0.04)*
APOE4	5.56 (0.13)**	3.60 (0.12)**	1.34 (0.05)	0.44 (0.05)
*SCARB 1*
CC	5.30 (0.09)	3.29 (0.08)	1.26 (0.04)	0.45 (0.03)
CT	5.29 (0.07)	3.40 (0.07)	1.32 (0.03)	0.33 (0.03) ^#
TT	5.56 (0.13)	3.66 (0.12) ^#	1.27 (0.05)	0.39 (0.05)
*PPARα*
CC	5.35 (0.05)	3.42 (0.05)	1.30 (0.02)	0.37 (0.02)
CG	5.31 (0.21)	3.33 (0.19)	1.29 (0.09)	0.58 (0.08)^{# #}
		WOMEN
*APOE*
APOE3	5.34 (0.05)	3.31 (0.05)	1.42 (0.02)	0.31 (0.02)
APOE2	5.04 (0.10)*	2.74 (0.09)*	1.48 (0.04)	0.30 (0.04)
APOE4	5.39 (0.09)**	3.35 (0.08)**	1.45 (0.03)	0.30 (0.03)
*SCARB 1*
CC	5.31 (0.07)	3.27 (0.06)	1.42 (0.03)	0.30 (0.03)
CT	5.29 (0.06)	3.23 (0.05)	1.42 (0.02)	0.32 (0.02)
TT	5.25 (0.10)	3.09 (0.09)	1.49 (0.04)	0.29 (0.04)
*PPARα*
CC	5.28 (0.04)	3.21 (0.04)	1.42 (0.03)	0.31 (0.02)
CG	5.54 (0.18)	3.43 (0.16)	1.41 (0.02)	0.36 (0.07)

Data adjusted by age and body mass index.
APOE2 - carriers of the ϵ 2/2 and ϵ 2/3 genotype, APOE3 - carriers of the ϵ 3/3 genotype, and APOE4 - carriers of the ϵ 3/4 and ϵ 4/4 genotype.
* p <0.05 compared with APOE3 genotype; ** p <0.05 compared with APOE2 genotype; ^# p <0.05 compared with SCARB1 genotype CC; ^## p <0.05 compared with PPARα genotype CC.
Abrevations: APOE apolipoprotein E, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, LnTG logarithmically transformed triglycerides, PPARα Peroxisome proliferator-activated receptor-alpha, SE Standard Error, SCARB1 Scavenger Receptor Class B Type 1, TC total cholesterol.

ISSN: 1476-511X