Table 3 Genotype and Allele distributions in patients with CAD and control participants
Total | Man | Woman | |||||||
|---|---|---|---|---|---|---|---|---|---|
Variants | CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value | CAD n (%) | Control n (%) | P value |
rs605143 (SNP1) | |||||||||
genotype | |||||||||
G/G | 175 (37.2) | 187 (30.0) | 121 (37) | 113 (28.2) | 54 (37.5) | 74 (33.0) | |||
A/G | 214 (45.4) | 297 (47.6) | 148 (45.3) | 196 (49.0) | 66 (45.8) | 101 (45.1) | |||
A/A | 82 (17.4) | 140 (22.4) | 0.02 | 58 (17.7) | 91 (22.8) | 0.03 | 24 (16.7) | 49 (21.9) | 0.424 |
Dominant model | |||||||||
GG | 175 (37.2) | 187 (30.0) | 121 (37) | 113 (28.2) | 54 (37.5) | 74 (33.0) | |||
AG + AA | 296(62.8) | 437 (70) | 0.014 | 206 (63.0) | 287 (71.8) | 0.013 | 90 (62.5) | 150 (67.0) | 0.433 |
Recessive model | |||||||||
AA | 82 (17.4) | 140 (22.4) | 58 (17.7) | 91 (22.8) | 24 (16.7) | 49 (21.9) | |||
AG + GG | 389 (82.6) | 484 (77.6) | 0.048 | 269 (82.3) | 309 (77.3) | 0.098 | 120 (83.4) | 175 (78.1) | 0.232 |
Additive model | |||||||||
AG | 214 (45.4) | 297 (47.6) | 148 (45.3) | 196 (49.0) | 66 (45.8) | 101 (45.1) | |||
GG + AA | 257 (54.6) | 327 (52.4) | 0.501 | 179 (54.7) | 204 (51.0) | 0.332 | 78 (54.2) | 123 (54.9) | 0.915 |
Allele | |||||||||
G | 564 (59.9) | 671 (53.8) | 390 (59.6) | 422 (52.8) | 174 (60.4) | 199 (44.4) | |||
A | 378 (40.1) | 577 (46.2) | 0.005 | 264 (40.4) | 378 (47.2) | < 0.001 | 114 (39.6) | 249 (55.6) | 0.222 |
rs565470(SNP2) | |||||||||
genotype | |||||||||
T/T | 169 (35.9) | 308 (49.4) | 104 (31.8) | 192 (48.0) | 65 (45.1) | 116 (51.8) | |||
C/T | 221 (46.9) | 271 (43.4) | 153 (46.8) | 181 (45.2) | 68 (47.2) | 90 (40.2) | |||
C/C | 81 (17.2) | 45 (7.2) | < 0.001 | 70 (21.4) | 27 (6.8) | < 0.001 | 11 (7.6) | 18 (8.0) | 0.392 |
Dominant model | |||||||||
TT | 169 (35.90) | 308 (49.4) | 104 (31.8) | 192 (48.0) | 65 (45.1) | 116 (51.8) | |||
CC + CT | 302 (64.1) | 316 (50.6) | < 0.001 | 223 (68.2) | 208 (52.0) | < 0.001 | 79 (54.9) | 108 (48.2) | 0.24 |
Recessive model | |||||||||
CC | 81 (17.20) | 45 (7.2) | 70 (21.4) | 27 (6.8) | 11 (7.6) | 18 (8.0) | |||
TT + CT | 390 (82.8) | 579 (92.8) | < 0.001 | 257 (78.6) | 373 (93.2) | < 0.001 | 133 (92.4) | 206 (92.0) | 1 |
Additive model | |||||||||
CT | 221 (46.9) | 271 (43.4) | 153 (46.8) | 181 (45.2) | 68 (47.2) | 90 (40.2) | |||
TT + CC | 250 (53.1) | 353 (56.6) | 0.269 | 174 (53.2) | 219 (54.8) | 0.709 | 76 (52.8) | 134 (59.8) | 0.196 |
Allele | |||||||||
T | 559 (59.3) | 887 (71.1) | 361 (55.2) | 565 (70.6) | 198 (68.8) | 322 (71.9) | |||
C | 383 (40.7) | 361 (28.9) | < 0.001 | 293 (44.8) | 235 (29.4) | < 0.001 | 90 (31.2) | 126 (28.1) | 0.407 |