Skip to main content

Table 3 Genotype and Allele distributions in patients with CAD and control participants

From: Association of COL4A1 genetic polymorphisms with coronary artery disease in Uygur population in Xinjiang, China

  Total Man Woman
Variants CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value CAD n (%) Control n (%) P value
rs605143 (SNP1)          
genotype          
G/G 175 (37.2) 187 (30.0)   121 (37) 113 (28.2)   54 (37.5) 74 (33.0)  
A/G 214 (45.4) 297 (47.6)   148 (45.3) 196 (49.0)   66 (45.8) 101 (45.1)  
A/A 82 (17.4) 140 (22.4) 0.02 58 (17.7) 91 (22.8) 0.03 24 (16.7) 49 (21.9) 0.424
Dominant model          
GG 175 (37.2) 187 (30.0)   121 (37) 113 (28.2)   54 (37.5) 74 (33.0)  
AG + AA 296(62.8) 437 (70) 0.014 206 (63.0) 287 (71.8) 0.013 90 (62.5) 150 (67.0) 0.433
Recessive model          
AA 82 (17.4) 140 (22.4)   58 (17.7) 91 (22.8)   24 (16.7) 49 (21.9)  
AG + GG 389 (82.6) 484 (77.6) 0.048 269 (82.3) 309 (77.3) 0.098 120 (83.4) 175 (78.1) 0.232
Additive model          
AG 214 (45.4) 297 (47.6)   148 (45.3) 196 (49.0)   66 (45.8) 101 (45.1)  
GG + AA 257 (54.6) 327 (52.4) 0.501 179 (54.7) 204 (51.0) 0.332 78 (54.2) 123 (54.9) 0.915
Allele          
G 564 (59.9) 671 (53.8)   390 (59.6) 422 (52.8)   174 (60.4) 199 (44.4)  
A 378 (40.1) 577 (46.2) 0.005 264 (40.4) 378 (47.2) < 0.001 114 (39.6) 249 (55.6) 0.222
rs565470(SNP2)          
genotype          
T/T 169 (35.9) 308 (49.4)   104 (31.8) 192 (48.0)   65 (45.1) 116 (51.8)  
C/T 221 (46.9) 271 (43.4)   153 (46.8) 181 (45.2)   68 (47.2) 90 (40.2)  
C/C 81 (17.2) 45 (7.2) < 0.001 70 (21.4) 27 (6.8) < 0.001 11 (7.6) 18 (8.0) 0.392
Dominant model          
TT 169 (35.90) 308 (49.4)   104 (31.8) 192 (48.0)   65 (45.1) 116 (51.8)  
CC + CT 302 (64.1) 316 (50.6) < 0.001 223 (68.2) 208 (52.0) < 0.001 79 (54.9) 108 (48.2) 0.24
Recessive model          
CC 81 (17.20) 45 (7.2)   70 (21.4) 27 (6.8)   11 (7.6) 18 (8.0)  
TT + CT 390 (82.8) 579 (92.8) < 0.001 257 (78.6) 373 (93.2) < 0.001 133 (92.4) 206 (92.0) 1
Additive model          
CT 221 (46.9) 271 (43.4)   153 (46.8) 181 (45.2)   68 (47.2) 90 (40.2)  
TT + CC 250 (53.1) 353 (56.6) 0.269 174 (53.2) 219 (54.8) 0.709 76 (52.8) 134 (59.8) 0.196
Allele          
T 559 (59.3) 887 (71.1)   361 (55.2) 565 (70.6)   198 (68.8) 322 (71.9)  
C 383 (40.7) 361 (28.9) < 0.001 293 (44.8) 235 (29.4) < 0.001 90 (31.2) 126 (28.1) 0.407
  1. CAD, Coronary artery disease; N, number of participants; SNP, single-nucleotide polymorphism.