Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations

Zeng, Xiao-Na; Yin, Rui-Xing; Huang, Ping; Huang, Ke-Ke; Wu, Jian; Guo, Tao; Lin, Quan-Zhen; Aung, Lynn Htet Htet; Wu, Jin-Zhen; Wang, Yi-Ming

doi:10.1186/1476-511X-12-156

Lipids in Health and Disease

Table 6 Correlative factors for serum lipid parameters between males and females in both ethnic groups

From: Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations

Lipid parameter	Relative factor	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
Mulao / Male
TC	Body mass index	0.103	0.030	0.197	3.418	0.001
	Alcohol consumption	0.201	0.100	0.116	2.018	0.045
TG	Waist circumference	0.097	0.022	0.250	4.419	0.000
	Alcohol consumption	0.516	0.215	0.136	2.400	0.017
HDL-C	Waist circumference	−0.013	0.003	−0.227	−4.022	0.000
	Alcohol consumption	0.112	0.033	0.194	3.428	0.001
LDL-C	Body mass index	0.046	0.017	0.154	2.651	0.008
	Alcohol consumption	−0.126	0.057	−0.128	−0.128	0.028
ApoA1	Alcohol consumption	0.141	0.027	0.293	5.279	0.000
	Pulse pressure	0.004	0.002	0.144	2.589	0.010
	Blood glucose	−0.029	0.012	−0.129	−2.320	0.021
ApoB	Waist circumference	0.012	0.004	0.172	2.957	0.003
ApoA1/ApoB	Waist circumference	−0.019	0.005	−0.235	−4.158	0.000
	Alcohol consumption	0.141	0.044	0.179	3.197	0.002
	Blood glucose	−0.042	0.021	−0.115	−2.034	0.043
Mulao / Female
TC	Age	0.015	0.004	0.196	3.803	0.000
	Body mass index	0.053	0.019	0.139	2.695	0.007
TG	Alcohol consumption	1.434	0.306	0.237	4.683	0.000
	Waist circumference	0.024	0.006	0.189	3.728	0.000
HDL-C	Body mass index	−0.032	0.007	−0.230	−4.459	0.000
LDL-C	Age	0.013	0.003	0.228	4.500	0.000
	Body mass index	0.056	0.015	0.187	3.682	0.000
ApoB	Cigarette smoking	1.217	0.302	0.205	4.035	0.000
	Waist circumference	0.010	0.003	0.182	3.581	0.000
	Age	0.003	0.001	0.118	2.321	0.021
ApoA1/ApoB	Age	−0.010	0.004	−0.133	−2.526	0.012
Han / Male
TC	Diastolic blood pressure	0.028	0.005	0.305	5.788	0.000
	Alcohol consumption	0.242	0.067	0.191	3.637	0.000
TG	Waist circumference	0.065	0.018	0.200	3.653	0.000
	Cigarette smoking	0.903	0.223	0.216	4.047	0.000
	Blood glucose	0.341	0.080	0.237	4.239	0.000
	Diastolic blood pressure	0.045	0.012	0.203	3.708	0.000
	Age	−0.019	0.009	−0.121	−2.185	0.030
HDL-C	Waist circumference	−0.012	0.003	−0.231	−4.236	0.000
	Alcohol consumption	0.096	0.026	0.201	3.673	0.000
LDL-C	Cigarette smoking	−0.281	0.072	−0.212	−3.926	0.000
	Body mass index	0.041	0.011	0.205	3.803	0.000
ApoA1	Alcohol consumption	0.127	0.017	0.395	7.437	0.000
	Body mass index	−0.008	0.003	−0.120	−2.338	0.020
	Cigarette smoking	0.051	0.023	0.114	2.161	0.031
ApoB	Waist circumference	0.004	0.001	0.154	2.716	0.007
	Diastolic blood pressure	0.004	0.001	0.226	4.559	0.000
	Alcohol consumption	0.048	0.011	0.208	4.289	0.000
	Body mass index	0.010	0.003	0.208	3.744	0.000
	Blood glucose	0.018	0.005	0.167	3.443	0.001
ApoA1/ApoB	Body mass index	−0.027	0.006	−0.251	−4.215	0.000
	Cigarette smoking	0.110	0.039	0.152	2.838	0.005
	Waist circumference	−0.010	0.003	−0.174	−2.909	0.004
	Alcohol consumption	0.071	0.029	0.134	2.474	0.014
Han/Female
TC	Age	0.021	0.003	0.329	7.023	0.000
	Body mass index	0.065	0.015	0.205	4.378	0.000
TG	Waist circumference	0.050	0.008	0.301	6.277	0.000
	Diastolic blood pressure	0.017	0.006	0.156	3.072	0.002
	Blood glucose	0.103	0.039	0.130	2.666	0.008
	Age	−0.009	0.004	−0.109	−2.115	0.035
HDL-C	Systolic blood pressure	−0.006	0.002	−0.188	−3.282	0.001
	Age	0.007	0.002	0.171	2.983	0.003
LDL-C	Age	0.019	0.003	0.337	6.977	0.000
	Waist circumference	0.020	0.005	0.176	3.756	0.000
	Cigarette smoking	−0.601	0.216	−0.135	−2.785	0.006
ApoA1	Alcohol consumption	0.185	0.064	0.145	2.903	0.004
ApoB	Waist circumference	0.003	0.002	0.116	1.725	0.085
	Pulse pressure	0.001	0.001	0.110	2.187	0.029
	Blood glucose	0.017	0.006	0.145	3.065	0.002
	Body mass index	0.015	0.004	0.254	3.759	0.000
	Cigarette smoking	−0.167	0.046	−0.169	−3.600	0.000
	Age	0.002	0.001	0.167	3.166	0.002
ApoA1/ApoB	Systolic blood pressure	−0.006	0.001	−0.230	−4.807	0.000
	Cigarette smoking	0.616	0.117	0.243	5.261	0.000
	Body mass index	−0.035	0.007	−0.225	−4.853	0.000
	Blood glucose	−0.029	0.015	−0.093	−1.973	0.049

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The correlative factors were determined by multivariable linear regression analysis with stepwise modeling.

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ISSN: 1476-511X

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