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Table 5 Changes seen in the survival, FR generated, and LXA 4 , TNF-α and IL-6 secreted by PC-3 cells when supplemented with different doses of fatty acids for 48 hours

From: Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro

Treatment PC-3% survival FR generated% of control LXA4 levels% of control IL-6% of control TNF-α% of control
Control 100 ± 1.86 100 ± 2.09 100 ± 2.60 100 ± 0.07 100 ± 6.34
LA 50 μM 105.00 ± 1.81* 104.31 ± 6.33* 56.00 ± 6.61*** 67.06 ± 6.11** 53.75 ± 6.67***
LA 150 μM 95.00 ± 4.62* 102.65 ± 6.77* 72.00 ± 4.00** 71.18 ± 4.58** 71.25 ± 3.97**
GLA 25 μM 88.61 ± 4.39* 68.49 ± 3.35** 187.49 ± 2.11*** 158.71 ± 9.66*** 137.00 ± 3.94**
GLA 50 μM 82.53 ± 3.72** 74.67 ± 2.34** 179.34 ± 0.79*** 148.57 ± 8.14*** 148.81 ± 4.64***
GLA 75 μM 67.74 ± 3.81*** 58.97 ± 5.11*** 200.20 ± 2.94*** 174.32 ± 7.32*** 259.95 ± 6.95***
AA 50 μM 80.35 ± 1.21** 55.81 ± 2.99*** 108.90 ± 0.39* 100.66 ± 5.24 73.22 ± 0.91**
AA 100 μM 60.08 ± 4.04*** 76.32 ± 3.80** 99.17 ± 1.07 98.22 ± 1.32 65.50 ± 1.28**
ALA 50 μM 93.14 ± 1.66* 112.27 ± 6.82* 56.41 ± 5.44*** 57.14 ± 4.58*** 75.00 ± 3.90**
ALA150μM 70.59 ± 1.51** 160.86 ± 7.10*** 48.72 ± 6.92*** 45.71 ± 7.70*** 83.75 ± 6.54**
EPA 50 μM 83.36 ± 6.65** 90.84 ± 6.30* 88.50 ± 0.75* 97.77 ± 2.13 80.41 ± 3.29**
EPA 100 μM 77.83 ± 5.55** 76.98 ± 4.97** 89.54 ± 1.22* 101.33 ± 5.59 81.13 ± 1.00**
DHA 50 μM 88.94 ± 6.91* 80.99 ± 2.88** 81.43 ± 1.09** 67.64 ± 1.95** 69.14 ± 2.85**
DHA100μM 75.88 ± 3.55** 67.00 ± 6.24** 76.84 ± 0.69** 57.71 ± 2.78*** 66.69 ± 1.60**
  1. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control.