Comparison of Nrf2 with respect to liver histopathology. Fresh sections were stained with H & E to demonstrate lipid accumulation and flammatory cell. a. Wide type mouse liver induced by control diet. b. Wide type mouse liver induced by high fatty diet with mild hepatosteatosis consisting of mixed microvesicular and macrovesicular fat accumulation. c. Nrf2-null mouse liver induced by control diet with mild granular degeneration. d. Nrf2-null mouse liver induced by high fatty diet with severe and large scale hepatosteatosis consisting of macrovesicular fat accumulation, and mild inflammatory cell infiltration. Arrow indicates infiltrated inflamematory cells.