Atherosclerotic lesion areas in ascending and thoracic aorta stained with Oil Red O (n = 6). a- e the aorta stained with Oil Red O in five groups, a: W-T group; b: AS group; c: Simva group; d: L-4F group; e: Simva + L-4F group. L-4F was administered intraperitoneally daily at a dose of 1 mg/kg/d, simvastatin intragastrically at a dose of 5 mg/kg/d and the combination group was given L-4F 1 mg/kg/d and simvastatin 5 mg/kg/d. f Lesion area was expressed as a percentage of total area. Simvastatin and L-4F equally reduced the lesion areas, and when they used together the lesion areas were the least.1P < 0.05, 2P < 0.001, vs. AS group; aP < 0.05, bP < 0.001, vs. Simva group;*P < 0.05, **P < 0.001, vs. L-4F group.