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Table 3 Product: precursor ratio desaturase activities in 5 lipid pools with effects of African Caribbean and Asian Indian ethnicity relative to White European derived from linear regression models incorporating ethnicity and potential confounding variables

From: Ethnic variation in the activity of lipid desaturases and their relationships with cardiovascular risk factors in control women and an at-risk group with previous gestational diabetes mellitus: a cross-sectional study

 

White European n = 89 (median, IQ range)

African-Caribbean n = 53 (coefficient, 95%CI)

Asian Indian n = 56 (coefficient, 95%CI)

Stearoyl-CoA desaturase C16

     FF

0.15 (0.12,0.20)

−0.05 (−0.07,−0.04) §

−0.04 (−0.05,−0.02) §

     TG

0.17 (0.14,0.20)

−0.04 (−0.05,−0.03) §

−0.03 (−0.04,−0.02) §

     CE

0.25 (0.20,0.30)

−0.08 (−0.10,−0.04) §

−0.06 (−0.09,−0.03) §

     PL

0.02 (0.02,0.03)

−0.007 (−0.010,−0.004) §

−0.005 (−0.008,−0.002) §

Stearoyl-CoA desaturase C18

     FF

3.8 (3.0,5.0)

−0.14 (−0.24,0.03) *

−0.06 (−0.17,0.05)

     TG

11.3 (9.7,13.8)

−0.23 (−0.36,−0.09) †

−0.15 (−0.30,−0.01) *

     CE

20.3 (16.8,23.5)

−0.13 (−0.24,−0.02) *

−0.09 (−0.21,,0.03)

     PL

0.84 (0.73,0.94)

−0.13 (−0.17,−0.09) §

−0.13 (−0.16,−0.09) §

n-6 Δ-6 desaturase

     FF

0.00 (0.00,0.01)

0.003 (−0.002,0.008)

−0.002 (−0.007,0.004)

     TG

0.01 (0.01,0.02)

0.001 (−0.002,0.005)

0.002 (−0.002,0.006)

     CE

0.01 (0.01.0.01)

−0.001 (−0.002,0.001)

−0.003 (−0.004,−0.001) †

     PL

0.09 (0.07,0.11)

−0.010 (−0.021,−0.001) *

−0.025 (−0.036,−0.014) §

n-6 Δ-5 desaturase

     FF

2.1 (0.0,12.5)

0.16 (−0.31,0.62)

0.51 (0.00,1.01) *

     TG

4.4 (3.2,5.5)

0.17 (−0.01,0.35)

0.01 (−0.19,0.20)

     CE

8.9 (7.4,10.8)

0.29 (0.13,0.45) †

0.14 (−0.04,0.32)

     PL

2.9 (2.2,3.5)

0.13 (0.04,0.22) †

0.12 (0.02,0.22) *

n-3 Δ desaturase

     FF

0.00 (0.00,0.20)

0.22 (−0.00,0.44)

−0.10 (−0.34,0.10)

     TG

0.18 (0.11,0.30)

0.16 (0.03,0.29) *

0.09 (−0.05,0.23)

     CE

1.28 (0.92,1.79)

0.12 (−0.30,0.55)

0.28 (−0.18, 0.75)

     PL

2.78 (1.79,4.43)

−0.03 (−0.33,0.26)

−0.09 (−0.40,0.23)

  1. Abbreviations: TF total fatty acids; FF free fatty acids; TG triglycerides; CE cholesterol esters; PL phospholipids.
  2. Significant, independent effects of ethnicity on desaturase activity were identified with regression models incorporating ethnicity and potential confounding variables, according to the general structure: desaturase activity = b1.(African Caribbean ethnicity) + b2.(Asian Indian ethnicity) + b3.(BMI) + b4.(waist circumference) + b5.(triglycerides) + b6.(HDL cholesterol).
  3. Significances * p < 0.05; † p < 0.01; § p < 0.001 refer to the significance of coefficients b1 and b2 and give the significance of the effects of African Caribbean and Asian Indian ethnicity, respectively, relative to white European ethnicity.
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Lipids in Health and Disease

ISSN: 1476-511X