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Table 3 Product: precursor ratio desaturase activities in 5 lipid pools with effects of African Caribbean and Asian Indian ethnicity relative to White European derived from linear regression models incorporating ethnicity and potential confounding variables

From: Ethnic variation in the activity of lipid desaturases and their relationships with cardiovascular risk factors in control women and an at-risk group with previous gestational diabetes mellitus: a cross-sectional study

  White European n = 89 (median, IQ range) African-Caribbean n = 53 (coefficient, 95%CI) Asian Indian n = 56 (coefficient, 95%CI)
Stearoyl-CoA desaturase C16
     FF 0.15 (0.12,0.20) −0.05 (−0.07,−0.04) § −0.04 (−0.05,−0.02) §
     TG 0.17 (0.14,0.20) −0.04 (−0.05,−0.03) § −0.03 (−0.04,−0.02) §
     CE 0.25 (0.20,0.30) −0.08 (−0.10,−0.04) § −0.06 (−0.09,−0.03) §
     PL 0.02 (0.02,0.03) −0.007 (−0.010,−0.004) § −0.005 (−0.008,−0.002) §
Stearoyl-CoA desaturase C18
     FF 3.8 (3.0,5.0) −0.14 (−0.24,0.03) * −0.06 (−0.17,0.05)
     TG 11.3 (9.7,13.8) −0.23 (−0.36,−0.09) −0.15 (−0.30,−0.01) *
     CE 20.3 (16.8,23.5) −0.13 (−0.24,−0.02) * −0.09 (−0.21,,0.03)
     PL 0.84 (0.73,0.94) −0.13 (−0.17,−0.09) § −0.13 (−0.16,−0.09) §
n-6 Δ-6 desaturase
     FF 0.00 (0.00,0.01) 0.003 (−0.002,0.008) −0.002 (−0.007,0.004)
     TG 0.01 (0.01,0.02) 0.001 (−0.002,0.005) 0.002 (−0.002,0.006)
     CE 0.01 (0.01.0.01) −0.001 (−0.002,0.001) −0.003 (−0.004,−0.001)
     PL 0.09 (0.07,0.11) −0.010 (−0.021,−0.001) * −0.025 (−0.036,−0.014) §
n-6 Δ-5 desaturase
     FF 2.1 (0.0,12.5) 0.16 (−0.31,0.62) 0.51 (0.00,1.01) *
     TG 4.4 (3.2,5.5) 0.17 (−0.01,0.35) 0.01 (−0.19,0.20)
     CE 8.9 (7.4,10.8) 0.29 (0.13,0.45) 0.14 (−0.04,0.32)
     PL 2.9 (2.2,3.5) 0.13 (0.04,0.22) 0.12 (0.02,0.22) *
n-3 Δ desaturase
     FF 0.00 (0.00,0.20) 0.22 (−0.00,0.44) −0.10 (−0.34,0.10)
     TG 0.18 (0.11,0.30) 0.16 (0.03,0.29) * 0.09 (−0.05,0.23)
     CE 1.28 (0.92,1.79) 0.12 (−0.30,0.55) 0.28 (−0.18, 0.75)
     PL 2.78 (1.79,4.43) −0.03 (−0.33,0.26) −0.09 (−0.40,0.23)
  1. Abbreviations: TF total fatty acids; FF free fatty acids; TG triglycerides; CE cholesterol esters; PL phospholipids.
  2. Significant, independent effects of ethnicity on desaturase activity were identified with regression models incorporating ethnicity and potential confounding variables, according to the general structure: desaturase activity = b1.(African Caribbean ethnicity) + b2.(Asian Indian ethnicity) + b3.(BMI) + b4.(waist circumference) + b5.(triglycerides) + b6.(HDL cholesterol).
  3. Significances * p < 0.05; p < 0.01; § p < 0.001 refer to the significance of coefficients b1 and b2 and give the significance of the effects of African Caribbean and Asian Indian ethnicity, respectively, relative to white European ethnicity.